Jump to: navigation, search

Decarboxylation is any chemical reaction in which a carboxyl group (-COOH) is split off from a compound as carbon dioxide (CO2).

In biochemistry

Common biosynthetic decarboxylations of amino acids to amines are:

Other decarboxylation reactions from the citric acid cycle include:

Enzymes that catalyze decarboxylations are called decarboxylases or, more formally, carboxy-lyases (EC number 4.1.1).

In organic chemistry

Chemical decarboxylations reactions often require extensive heating in high-boiling solvents. Copper salts are often added as catalysts. Also the addition of catalytic amounts of cyclohexen-2-one has been reported to catalyze the decarboxylation of amino acids. Decarboxylations are especially easy for beta-keto acids due to the formation of a cyclic transition state for instance in Knoevenagel condensations. The Barton decarboxylation and Hunsdiecker reaction are radical reactions.

See also

de:Decarboxylierung it:Decarbossilazione nl:Decarboxylering sv:Dekarboxylering