Dantron

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Dantron
Systematic (IUPAC) name
1,8-dihydroxyanthracene-9,10-dione
Identifiers
CAS number 117-10-2
ATC code A06AB03 A06AG03
PubChem 2950
DrugBank DB04816
Chemical data
Formula C14H8O4 
Mol. mass 240.211 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability ?
Metabolism ?
Half life ?
Excretion ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes Oral, rectal (enema)

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Dantron (INN), also known as chrysazin or 1,8-dihydroxyanthraquinone, is an organic substance, formally derived from anthraquinone by the replacement of two hydrogen atoms by hydroxyl groups (–OH). It is used in some countries as a stimulant laxative.

It should not be confused with ondansetron, an unrelated drug that was marketed in South Africa under the trade name "Dantron".

Medical uses

In the USA, dantron is not used because it is considered to be a carcinogen.[1]

In the UK it is considered a possible carcinogen and so its licence is restricted to patients who already have a diagnosis of terminal cancer. It is mainly used in palliative care to counteract the constipating effects of opioids. Its British Approved Name was danthron, but it has now been changed to "dantron", the recommended International Nonproprietary Name.[2]

Dantron has the notable side-effect of causing red-colored urine.

References


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