dTMP kinase

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In enzymology, a dTMP kinase (EC 2.7.4.9) is an enzyme that catalyzes the chemical reaction

ATP + dTMP ADP + dTDP

Thus, the two substrates of this enzyme are ATP and dTMP, whereas its two products are ADP and dTDP.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:dTMP phosphotransferase. Other names in common use include thymidine monophosphate kinase, thymidylate kinase, thymidylate monophosphate kinase, thymidylic acid kinase, thymidylic kinase, deoxythymidine 5'-monophosphate kinase, TMPK, and thymidine 5'-monophosphate kinase. This enzyme participates in pyrimidine metabolism.

Structural studies

As of late 2007, 40 structures have been solved for this class of enzymes, with PDB accession codes 1E2D, 1E2E, 1E2F, 1E2G, 1E2Q, 1E98, 1E99, 1E9A, 1E9B, 1E9C, 1E9D, 1E9E, 1E9F, 1G3U, 1GSI, 1GTV, 1MRN, 1MRS, 1N5I, 1N5J, 1N5K, 1N5L, 1NMX, 1NMY, 1NMZ, 1NN0, 1NN1, 1NN3, 1NN5, 1TMK, 1W2G, 1W2H, 2CCG, 2CCJ, 2CCK, 2PBR, 2TMK, 3TMK, 4TMK, and 5TMP.

References

  • IUBMB entry for 2.7.4.9
  • BRENDA references for 2.7.4.9 (Recommended.)
  • PubMed references for 2.7.4.9
  • PubMed Central references for 2.7.4.9
  • Google Scholar references for 2.7.4.9
  • Hurwitz J (1959). "The enzymatic incorporation of ribonucleotides into polydeoxynucleotide material". J. Biol. Chem. 234: 2351&ndash, 2358.
  • Kielley RK (1970). "Purification and properties of thymidine monophosphate kinase from mouse hepatoma". J. Biol. Chem. 245: 4204&ndash, 12. PMID 4323166.
  • Nelson DJ, Carter CE (1969). "Purification and characterization of Thymidine 5-monophosphate kinase from Escherichia coli B". J. Biol. Chem. 244: 5254&ndash, 62. PMID 4899016.

External links

The CAS registry number for this enzyme class is 9014-43-1.

Gene Ontology (GO) codes


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