DCP1A

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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View/Edit Human

mRNA-decapping enzyme 1A is a protein that in humans is encoded by the DCP1A gene.[1]

Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway.[1]

Interactions

DCP1A has been shown to interact with DCP2[2] and UPF1.[2] It has also been shown to interact with GW182, a P-body marker.[3]

References

  1. 1.0 1.1 "Entrez Gene: DCP1A DCP1 decapping enzyme homolog A (S. cerevisiae)".
  2. 2.0 2.1 Lykke-Andersen, Jens (Dec 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Mol. Cell. Biol. United States. 22 (23): 8114–21. doi:10.1128/MCB.22.23.8114-8121.2002. ISSN 0270-7306. PMC 134073. PMID 12417715.
  3. EYSTATHIOY, THEOPHANY; JAKYMIW, ANDREW; CHAN, EDWARD K.L.; SÉRAPHIN, BERTRAND; COUGOT, NICOLAS; FRITZLER, MARVIN J. (2003-10-01). "The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies". RNA. 9 (10): 1171–1173. doi:10.1261/rna.5810203. ISSN 1355-8382. PMC 1370480. PMID 13130130.

Further reading




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