DAPK3

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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View/Edit Human

Death-associated protein kinase 3 is an enzyme that in humans is encoded by the DAPK3 gene.[1][2]

Function

Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis.[2]

Unlike most other mammalian genes, murine (rat and mouse) DAPK3 has undergone accelerated evolution and diverged from the tightly conserved consensus that is maintained from fish to human.[3]

Interactions

DAPK3 has been shown to interact with PAWR[4] and Death associated protein 6.[4]

References

  1. Kawai T, Matsumoto M, Takeda K, Sanjo H, Akira S (Mar 1998). "ZIP kinase, a novel serine/threonine kinase which mediates apoptosis". Molecular and Cellular Biology. 18 (3): 1642–51. doi:10.1128/mcb.18.3.1642. PMC 108879. PMID 9488481.
  2. 2.0 2.1 "Entrez Gene: DAPK3 death-associated protein kinase 3".
  3. Shoval Y, Pietrokovski S, Kimchi A (Oct 2007). "ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene". PLoS Genetics. 3 (10): 1884–93. doi:10.1371/journal.pgen.0030180. PMC 2041995. PMID 17953487.
  4. 4.0 4.1 Kawai T, Akira S, Reed JC (Sep 2003). "ZIP kinase triggers apoptosis from nuclear PML oncogenic domains". Molecular and Cellular Biology. 23 (17): 6174–86. doi:10.1128/MCB.23.17.6174-6186.2003. PMC 180930. PMID 12917339.

Further reading



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