DAMGO

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Template:Chembox E number
DAMGO
IUPAC name (2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)
propanoyl]amino]propanoyl]amino]acetyl]-methylamino]-
N-(2-hydroxyethyl)-3-phenylpropanamide
Other names Ala2-MePhe4-Gly5-Enkephalin, DAGO, DAMGE
Identifiers
3D model (JSmol)
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Properties
C26H35N5O6
Molar mass 513.586 g/mol
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Overview

DAMGO ([D-Ala2, N-MePhe4, Gly-ol]-enkephalin) is a synthetic opioid peptide with high μ-opioid receptor specificity. It was synthesized as a biologically stable analog of δ-opioid receptor-preferring endogenous opioids, leu- and met-enkephalin.[1]

Its structure is H-Tyr-D-Ala-Gly-N-MePhe-Gly-OH.

References

  1. Handa BK, Land AC, Lord JA, Morgan BA, Rance MJ, Smith CF. "Analogues of β-LPH61–64 possessing selective agonist activity at μ-opiate receptors." European Journal of Pharmacology. 1981 Apr 9;70(4):531-40. PMID 6263640. doi:10.1016/0014-2999(81)90364-2




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