Cortisol sulfotransferase

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In enzymology, a cortisol sulfotransferase (EC is an enzyme that catalyzes the chemical reaction

3'-phosphoadenylyl sulfate + cortisol adenosine 3',5'-bisphosphate + cortisol 21-sulfate

Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and cortisol, whereas its two products are adenosine 3',5'-bisphosphate and cortisol 21-sulfate.

This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:cortisol 21-sulfotransferase. Other names in common use include glucocorticosteroid sulfotransferase, and glucocorticoid sulfotransferase.


  • IUBMB entry for
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  • Singer SS, Brill B (1982). "Enzymatic sulfation of steroids. XVII. The properties of the glucocorticoid sulfotransferase activity of guinea pig liver cytosol". Biochim. Biophys. Acta. 712: 590&ndash, 6. PMID 6957246.
  • Singer SS, Giera D, Johnson J, Sylvester S (1976). "Enzymatic sulfation of steroids: I. The enzymatic basis for the sex difference in cortisol sulfation by rat liver preparations". Endocrinology. 98: 963&ndash, 74. PMID 1278101.

External links

The CAS registry number for this enzyme class is 71427-08-2.

Gene Ontology (GO) codes