Corticotropin releasing hormone receptor 1

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Corticotropin releasing hormone receptor 1
Identifiers
Symbols CRHR1 ; CRF-R; CRF1; CRFR1; CRH-R1h; CRHR; CRHR1f
External IDs OMIM: 122561 MGI88498 HomoloGene20920
RNA expression pattern
PBB GE CRHR1 214619 at tn.png
PBB GE CRHR1 208593 x at tn.png
PBB GE CRHR1 211897 s at tn.png
More reference expression data
Orthologs

| | bgcolor="#C3FDB8" | Human | bgcolor="#C3FDB8" | Mouse |-

    | bgcolor="#C3FDB8" | Entrez 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 1394
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 12921

|-

     | bgcolor="#C3FDB8" | Ensembl
     | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| ENSG00000120088
     | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| ENSMUSG00000018634

|-

    | bgcolor="#C3FDB8" | Uniprot
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| P34998
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| Q0VGH2

|-

    | bgcolor="#C3FDB8" | Refseq
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" | XM_001128344 (mRNA)
XP_001128344 (protein)
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" |NM_007762 (mRNA)
NP_031788 (protein)

|-

    | bgcolor="#C3FDB8" | Location
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"|  Chr 17: 41.24 - 41.27 Mb 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"|  Chr 11: 103.95 -  103.99 Mb 

|-

|-

    | bgcolor="#C3FDB8" | Pubmed search 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [1]
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [2]
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Corticotropin releasing hormone receptor 1, also known as CRHR1, is a human gene.

The corticotropin-releasing hormone receptor binds to corticotropin-releasing hormone (MIM 122560), a potent mediator of endocrine, autonomic, behavioral, and immune responses to stress.[supplied by OMIM][1]

See also

References

  1. "Entrez Gene: CRHR1 corticotropin releasing hormone receptor 1".

Further reading

  • Taché Y, Martinez V, Wang L, Million M (2004). "CRF1 receptor signaling pathways are involved in stress-related alterations of colonic function and viscerosensitivity: implications for irritable bowel syndrome". Br. J. Pharmacol. 141 (8): 1321–30. doi:10.1038/sj.bjp.0705760. PMID 15100165.
  • McLean M, Bisits A, Davies J; et al. (1995). "A placental clock controlling the length of human pregnancy". Nat. Med. 1 (5): 460–3. PMID 7585095.
  • Polymeropoulos MH, Torres R, Yanovski JA; et al. (1995). "The human corticotropin-releasing factor receptor (CRHR) gene maps to chromosome 17q12-q22". Genomics. 28 (1): 123–4. doi:10.1006/geno.1995.1118. PMID 7590738.
  • Chen R, Lewis KA, Perrin MH, Vale WW (1993). "Expression cloning of a human corticotropin-releasing-factor receptor". Proc. Natl. Acad. Sci. U.S.A. 90 (19): 8967–71. PMID 7692441.
  • Ross PC, Kostas CM, Ramabhadran TV (1995). "A variant of the human corticotropin-releasing factor (CRF) receptor: cloning, expression and pharmacology". Biochem. Biophys. Res. Commun. 205 (3): 1836–42. doi:10.1006/bbrc.1994.2884. PMID 7811272.
  • Opdenakker G, Fiten P, Nys G; et al. (1994). "The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12". Genomics. 21 (2): 403–8. doi:10.1006/geno.1994.1283. PMID 7916328.
  • Vita N, Laurent P, Lefort S; et al. (1993). "Primary structure and functional expression of mouse pituitary and human brain corticotrophin releasing factor receptors". FEBS Lett. 335 (1): 1–5. PMID 8243652.
  • Donaldson CJ, Sutton SW, Perrin MH; et al. (1996). "Cloning and characterization of human urocortin". Endocrinology. 137 (5): 2167–70. PMID 8612563.
  • Liaw CW, Grigoriadis DE, Lovenberg TW; et al. (1997). "Localization of ligand-binding domains of human corticotropin-releasing factor receptor: a chimeric receptor approach". Mol. Endocrinol. 11 (7): 980–5. PMID 9178757.
  • Asakura H, Zwain IH, Yen SS (1997). "Expression of genes encoding corticotropin-releasing factor (CRF), type 1 CRF receptor, and CRF-binding protein and localization of the gene products in the human ovary". J. Clin. Endocrinol. Metab. 82 (8): 2720–5. PMID 9253360.
  • Gottowik J, Goetschy V, Henriot S; et al. (1998). "Labelling of CRF1 and CRF2 receptors using the novel radioligand, [3H]-urocortin". Neuropharmacology. 36 (10): 1439–46. PMID 9423932.
  • Grammatopoulos D, Dai Y, Chen J; et al. (1998). "Human corticotropin-releasing hormone receptor: differences in subtype expression between pregnant and nonpregnant myometria". J. Clin. Endocrinol. Metab. 83 (7): 2539–44. PMID 9661640.
  • Sakai K, Yamada M, Horiba N; et al. (1998). "The genomic organization of the human corticotropin-releasing factor type-1 receptor". Gene. 219 (1–2): 125–30. PMID 9757017.
  • Grammatopoulos DK, Dai Y, Randeva HS; et al. (2000). "A novel spliced variant of the type 1 corticotropin-releasing hormone receptor with a deletion in the seventh transmembrane domain present in the human pregnant term myometrium and fetal membranes". Mol. Endocrinol. 13 (12): 2189–202. PMID 10598591.
  • Lewis K, Li C, Perrin MH; et al. (2001). "Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7570–5. doi:10.1073/pnas.121165198. PMID 11416224.
  • Perrin MH, Fischer WH, Kunitake KS; et al. (2001). "Expression, purification, and characterization of a soluble form of the first extracellular domain of the human type 1 corticotropin releasing factor receptor". J. Biol. Chem. 276 (34): 31528–34. doi:10.1074/jbc.M101838200. PMID 11425856.
  • Pisarchik A, Slominski AT (2002). "Alternative splicing of CRH-R1 receptors in human and mouse skin: identification of new variants and their differential expression". FASEB J. 15 (14): 2754–6. doi:10.1096/fj.01-0487fje. PMID 11606483.
  • Graziani G, Tentori L, Portarena I; et al. (2002). "CRH inhibits cell growth of human endometrial adenocarcinoma cells via CRH-receptor 1-mediated activation of cAMP-PKA pathway". Endocrinology. 143 (3): 807–13. PMID 11861501.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • King JS, Bishop GA (2003). "The distribution and cellular localization of CRF-R1 in the vermis of the postnatal mouse cerebellum". Exp. Neurol. 178 (2): 175–85. PMID 12504877.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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