Constrictive pericarditis laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Huda A. Karman, M.D.

Overview

Constrictive pericarditis lab findings can show evidence of congestive heart failure, or associated protein losing enteropathy, nephrotic syndrome, and LFT abnormalities consistent with hepatic congestion and chylous ascites

Laboratory findings

  • Complete blood count (CBC)
  • Leukocytosis
  • Leukopenia
    • Malignancy and chemotherapeutic agents use
  • Hyponatremia or pseudohyponatremia
  • Contraction alkalosis (hypochloremia with hypercarbia)
  • Elevation of blood urea nitrogen (BUN) levels f
  • Serum creatinine levels are observed
  • Arterial blood gas measurement
  • Metabolic acidosis (ie, low pH and low bicarbonate),
  • Compensatory respiratory alkalosis (ie, decreased partial pressure of carbon dioxide
  • Elevated transaminase levels
  • Hypoalbuminemia (a protein-losing enteropathy (PLE)
  • Proteinuria (nephrotic range)
  • Elevated sedimentation rate (ESR), C-reactive protein (CRP) level (postpericardiotomy syndrome)
  • Brain natriuretic peptide (BNP), mildly increased (<150 ng/L)[1]
  • Antinuclear antibody (ANA) or rheumatoid factor (RF) (associated collagen vascular disorder)
  • Purified protein derivative (PPD) skin test (TB)

References

  1. Leya FS, Arab D, Joyal D, Shioura KM, Lewis BE, Steen LH; et al. (2005). "The efficacy of brain natriuretic peptide levels in differentiating constrictive pericarditis from restrictive cardiomyopathy". J Am Coll Cardiol. 45 (11): 1900–2. doi:10.1016/j.jacc.2005.03.050. PMID 15936624.

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