It has been suggested that Conservation (genetics) and Talk:Conserved sequence#Merge of Conservation (genetics) into Conserved sequence be merged into this article. (Discuss) Proposed since November 2007.
In biology, conserved sequences are similar or identical sequences that may occur within nucleic acids, proteins or polymeric carbohydrates within multiple species of organism or within different molecules produced by the same organism. In the case of cross species conservation, this indicates that a particular sequence may have been maintained by evolution despite speciation. The further back up the phylogenetic tree a particular conserved sequence may occur the more highly conserved it is said to be.
Conserved nucleic acid sequences
Conserved protein sequences
Shown below is an amino acid sequence alignment between two human zinc finger proteins, with GenBank accession numbers AAB24882 and AAB24881. Alignment was carried out using the clustalw sequence alignment program. Conserved amino acid sequences are marked by strings of on the third line of the sequence alignment. As can be seen from this alignment, these two proteins contain a number of conserved amino acid sequences.
Conserved polymeric carbohydrate sequences
Biological role of sequence conservation
Sequence similarities serve as evidence for structural and functional conservation, as well as of evolutionary relationships between the sequences. Consequently, comparative analysis is the primary means by which functional elements are identified.
- Thompson JD, Gibson TJ, Plewniak F, Jeanmougin F, Higgins DG (1997). The ClustalX windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Research, 25:4876-4882.
|40px||This biochemistry article is a stub. You can help Wikipedia by expanding it.|