Coiled-coil domain containing protein 120
Coiled coil domain containing protein 120 (CCDC120), also known as JM11 protein, is a protein that, in humans, is encoded by the CCDC120 gene. The function of CCDC120 has not been formally identified but structural components, conservation, and interactions can be identified computationally.
The mRNA transcript of CCDC120 contains a 120bp repeat near the 3' end.
Usher Syndrome 1C Binding Protein 1, CYTH2, MDFI, Centrosomal Protein 170kDa Pseudogene 1, and Keratin 15 have all been shown experimentally to interact with CCDC120  Other interactions have been identified by coexpression and datamining and can be seen in the figure.
Algorithms suggest a number of sites of Serine phosphorylation as well as a few sites of Threonine and Tyrosine phosphorylation. Many of these sites are conserved in Gorilla gorilla gorilla, Mus musculus, and Danio rerio. There is one potential N-Glycosylation site identified.
The protein structure of CCDC120 is predicted to contain, as the name implies, a 65 amino acid coiled coil from positions 109-173. Multiple algorithms identify 3 distinct sites where alpha-helical structures could form which are conserved in Gorilla gorilla gorilla and Danio rerio. Algorithms do not agree on any location for a beta sheet structure.
Algorithms suggest that CCDC120 has a promoter of 601bp, this promoter contains a number of possible transcription factor sites as shown in the figure.
References in Scientific Literature
CCDC120 was found to be upregulated under pulsed electromagnetic fields in human osteoblastlike cells. CCDC120 has a 7 base deletion in a Metastatic Olfactory Neuroblastoma. CCDC120 is downregulated after neonatal hypoxic-ischemic brain injury in rats.
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- Sollazzo V, Palmieri A, Pezzetti F, Massari L, Carinci F (August 2010). "Effects of pulsed electromagnetic fields on human osteoblastlike cells (MG-63): a pilot study". Clin. Orthop. Relat. Res. 468 (8): 2260–77. doi:10.1007/s11999-010-1341-5. PMC 2895828. PMID 20387020.
- Weiss GJ, Liang WS, Izatt T, Arora S, Cherni I, Raju RN, Hostetter G, Kurdoglu A, Christoforides A, Sinari S, Baker AS, Metpally R, Tembe WD, Phillips L, Von Hoff DD, Craig DW, Carpten JD (2012). "Paired tumor and normal whole genome sequencing of metastatic olfactory neuroblastoma". PLoS ONE. 7 (5): e37029. doi:10.1371/journal.pone.0037029. PMC 3359355. PMID 22649506.
- Kojima T, Ueda Y, Sato A, Sameshima H, Ikenoue T (February 2013). "Comprehensive gene expression analysis of cerebral cortices from mature rats after neonatal hypoxic-ischemic brain injury". J. Mol. Neurosci. 49 (2): 320–7. doi:10.1007/s12031-012-9830-5. PMID 22700374.