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Cohesin. Cohesin, binds sister chromatids together during metaphase (PDB: 1w1w).

Genetic data
Gene code: [1] ID#: GI:2570096
Protein Structure/Function
Structure: [2]1W1W

Cohesin is the protein responsible for binding the sister chromatids during mitosis after S phase. At metaphase, most cohesin is removed, except for some at the centromere. At Anaphase, securin, an inhibitory subunit of separase, is hydrolyzed. Separase hydrolyzes the remaining cohesin.

See also

External links

  • Michaelis C, Ciosk R, Nasmyth K (1997). "Cohesins: chromosomal proteins that prevent premature separation of sister chromatids". Cell. 91 (1): 35–45. PMID 9335333.
  • Guacci V, Koshland D, Strunnikov A (1997). "A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae". Cell. 91 (1): 47–57. PMID 9335334.
  • Tóth A, Ciosk R, Uhlmann F, Galova M, Schleiffer A, Nasmyth K (1999). "Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication". Genes Dev. 13 (3): 320–33. PMID 9990856.
  • Uhlmann F, Lottspeich F, Nasmyth K (1999). "Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1". Nature. 400 (6739): 37–42. doi:10.1038/21831. PMID 10403247.