Clebopride

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Clebopride
Systematic (IUPAC) name
4-amino-N-(1-benzylpiperidin-4-yl)-5-chloro-
2-methoxybenzamide
Identifiers
CAS number 55905-53-8
ATC code A03FA06
PubChem 2780
Chemical data
Formula C20H24ClN3O2 
Mol. mass 373.876 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes  ?

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Clebopride is a dopamine antagonist drug with antiemetic and prokinetic properties used to treat functional gastrointestinal disorders. Chemically, it is a substituted benzamide, closely related to metoclopramide.

A small Spanish study found that more adverse reactions are reported with clebopride than with metoclopramide, particularly extrapyramidal symptoms.[1]

References

  1. Cuena Boy R, Maciá Martínez MA (1998). "[Extrapyramidal toxicity caused by metoclopramide and clebopride: study of voluntary notifications of adverse effects to the Spanish Drug Surveillance System]". Atencion Primaria (in Spanish). 21 (5): 289–95. PMID 9608114.  Free full text

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