Citrate (pro-3S)-lyase

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In enzymology, a citrate (pro-3S)-lyase (EC is an enzyme that catalyzes the chemical reaction

citrate acetate + oxaloacetate

Hence, this enzyme has one substrate, citrate, and two products, acetate and oxaloacetate.

This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is citrate oxaloacetate-lyase (forming acetate from the pro-S carboxymethyl group of citrate). Other names in common use include citrase, citratase, citritase, citridesmolase, citrate aldolase, citric aldolase, citrate lyase, citrate oxaloacetate-lyase, and citrate oxaloacetate-lyase [(pro-3S)-CH2COO-->acetate]. This enzyme participates in citrate cycle (tca cycle) and two-component system - general.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1U5H, 1U5V, 1Z6K, and 2HJ0.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
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  • DAGLEY S, DAWES EA (1955). "Citridesmolase: its properties and mode of action". Biochim. Biophys. Acta. 17: 177&ndash, 84. PMID 13239657.
  • Dimroth P, Loyal R, Eggerer H (1977). "Characterization of the isolated transferase subunit of citrate lyase as a CoA-Transferase. Evidence against a covalent enzyme-substrate intermediate". Eur. J. Biochem. 80: 479&ndash, 88. PMID 336371.

External links

The CAS registry number for this enzyme class is 9012-83-3.

Gene Ontology (GO) codes