Citramalyl-CoA lyase

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In enzymology, a citramalyl-CoA lyase (EC is an enzyme that catalyzes the chemical reaction

(3S)-citramalyl-CoA acetyl-CoA + pyruvate

Hence, this enzyme has one substrate, (3S)-citramalyl-CoA, and two products, acetyl-CoA and pyruvate.

This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming). Other names in common use include citramalyl coenzyme A lyase, (+)-CMA-CoA lyase, and (3S)-citramalyl-CoA pyruvate-lyase. This enzyme participates in pyruvate metabolism and c5-branched dibasic acid metabolism.


  • IUBMB entry for
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  • Cooper RA, Kornberg HL (1964). "The utilization of itaconate by Pseudomonas sp". Biochem. J. 91: 82&ndash, 91. PMID 4284209.
  • Dimroth P, Buckel W, Loyal R, Eggerer H (1977). "Isolation and function of the subunits of citramalate lyase and formation of hybrids with the subunits of citrate lyase". Eur. J. Biochem. 80: 469&ndash, 77. PMID 923590.

External links

The CAS registry number for this enzyme class is 37290-68-9.

Gene Ontology (GO) codes