Cimicoxib

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Cimicoxib (UR-8880 trade name Cimalgex) is a non-steroidal anti-inflammatory drug (NSAID) used in veterinary medicine to treat dogs for pain and inflammation associated with osteoarthritis and for the management of pain and inflammation associated with surgery.[1] It acts as a COX-2 inhibitor.

Synthesis

Cimicoxib synthesis:[2]

Reaction of the imine with tosylisocyanate in the presence of potassium carbonate leads to what may be viewed as 2+3 cycloaddition of the nitrogen analogue of a ketene to form the imidazole ring.

References

  1. "European Public Assessment Report: Cimalgex (cimicoxib)". European Medicines Agency.
  2. Template:Cite doi

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