Chronic granulomatous disease

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Chronic granulomatous disease
ICD-10 D71.
ICD-9 758.0
OMIM 306400
DiseasesDB 2633
MedlinePlus 001239
eMedicine ped/1590  derm/719
MeSH D006105

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Chronic granulomatous disease (CGD) is a diverse group of hereditary diseases in which certain cells of the immune system have difficulty forming the reactive oxygen compounds (most importantly, the superoxide radical) used to kill certain ingested pathogens. This leads to the formation of granulomata in many organs[1]. CGD affects about 1 in 200,000 people in the United States, with at least 20 new cases diagnosed each year.[2]

This condition was first described in 1959 as "a fatal granulomatosis of childhood"[3]. The underlying cellular mechanism that causes chronic granulomatous disease was discovered in 1967, and research since that time has further elucidated the molecular mechanisms underlying the disease[4].

Pathophysiology

Two neutrophils among many red blood cells. Neutrophils are one type of cell affected by chronic granulomatous disease.

Phagocytes (i.e., neutrophils, monocytes, and macrophages) require an enzyme to produce reactive oxygen species to destroy bacteria after they ingest the bacteria in a process called phagocytosis. This enzyme is termed "phagocyte NADPH oxidase" (PHOX). The initial step in this process involves the one-electron reduction of molecular oxygen to produce Superoxide free radical. Superoxide then undergoes a further series of reactions to produce products such as peroxide, hydroxyl radical and hypochlorite. The reactive oxygen species this enzyme produces are toxic to bacteria and help the phagocyte kill them once they are ingested. Defects in one of the four essential subunits of this enzyme can all cause CGD of varying severity, dependent on the defect. There are over 410 known possible defects in the PHOX enzyme complex that can lead to chronic granulomatous disease[1].

Genetics

Most cases of chronic granulomatous disease are transmitted as a mutation on the X chromosome and are thus called an "X-linked trait"[5]. The affected gene on the X chromosome codes for the gp91 protein p91-PHOX (p is the weight of the protein in kDa; the g means glycoprotein). CGD can also be transmitted in an autosomal recessive fashion and affects other PHOX proteins. The type of mutation that causes both types of CGD are varied and may be deletions, frame-shift, nonsense, and missense[6][7].

A low level of NADPH, the cofactor required for superoxide synthesis, can lead to CGD. This has been reported in women who are homozygous for the genetic defect causing glucose-6-phosphate dehydrogenase deficiency (G6PD), which is characterised by reduced NADPH levels.

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Clinical manifestations

Classically, patients with chronic granulomatous disease will suffer from recurrent bouts of infection due to the decreased capacity of their immune system to fight off disease-causing organisms. The recurrent infections they acquire are specific and are, in decreasing order of frequency:

Microscopic image of the fungus, Aspergillus fumigatus, an organism that commonly causes disease in people with chronic granulomatous disease.

People with CGD are sometimes infected with unique organisms that usually do not cause disease in people with normal immune systems. Some of the organisms that cause disease in CGD patients are Staphylococcus aureus, Escheria coli, Klebsiella species, Aspergillus species, and Candida species.

Aspergillus has a unique propensity to cause infection in people with CGD. Of the Aspergillus species, Aspergillus fumigatus seems to be the one that most commonly causes disease.

Most people with CGD are diagnosed in childhood, usually before age 5 [5]. Early diagnosis is important since these people can be placed on antibiotics to ward off infections before they occur.

Laboratory findings

The nitroblue-tetrazolium (NBT) test is the original and most widely-known test for chronic granulomatous disease.[8] It is negative in CGD, and positive in normal individuals. This test depends upon the direct reduction of NBT by superoxide free radical to form an insoluble formazan. This test is simple to perform and gives rapid results, but only tells whether or not there is a problem with the PHOX enzymes, not how much they are affected. An advanced test called the cytochrome C reduction assay tells physicians how much superoxide a patient's phagocytes can produce. Once the diagnosis of CGD is established, a genetic analysis may be used to determine exactly which mutation is the underlying cause.

Treatment

Management of chronic granulomatous disease revolves around two goals: 1) diagnose the disease early so that antibiotics can be given to keep an infection from occurring, and 2) educate the patient about his or her condition so that prompt treatment can be given if an infection occurs.

Physicians often prescribe the antibiotic trimethoprim-sulfamethoxazole to prevent bacterial infections[9]. This drug also has the benefit of sparing the normal bacteria of the digestive tract. Fungal infection is commonly prevented with itraconazole[10], although a newer drug of the same type called voriconazole may be more effective[11]. The use of this drug for this purpose is still under scientific investigation.

Interferon, in the form of interferon gamma-1b (Actimmune®) is approved by the Food and Drug Administration for the prevention of infection in CGD. It has been shown to prevent infections in CGD patients by 70% and to reduce their severity. Although its exact mechanism is still not entirely understood, it has the ability to give CGD patients more immune function and therefore, greater ability to fight off infections. This therapy has been standard treatment for CGD for several years[12].

Gene therapy is currently being studied as a possible treatment for chronic granulomatous disease. CGD is well-suited for gene therapy since it is caused by a mutation in single gene which only affects one body system (the hematopoietic system). Viruses have been used to deliver a normal gp91 gene to rats with a mutation in this gene, and subsequently the phagocytes in these rats were able to produce oxygen radicals[13].

In 2006, two human patients with X-linked chronic granulomatous disease underwent gene therapy and blood cell precursor stem cell transplantation to their bone marrow. Both patients recovered from their CGD, clearing pre-existing infections and demonstrating increased oxidase activity in their neutrophils. However, long-term complications of this therapy are unknown[14].

Contraindicated medications

Chronic granulomatous disease is considered an absolute contraindication to the use of the following medications:

Prognosis

The prognosis of chronic granulomatous disease is guarded, with long-term outcomes closely tied to early diagnosis and early therapeutic intervention. With increasing treatment options for CGD the life-span for these patients is expected to also increase.

References

  1. 1.0 1.1 Heyworth P, Cross A, Curnutte J (2003). "Chronic granulomatous disease.". Curr Opin Immunol. 15 (5): 578–84. PMID 14499268. 
  2. Maryland Pao, M.D.; et al. (2004). "Cognitive Function in Patients With Chronic Granulomatous Disease: A Preliminary Report". Psychosomatics. 45 (June 2004): 230–4. PMID 15123849. 
  3. Bridges RA, Berendes H, Good RA. A fatal granulomatosis of childhood: the clinical, pathological, and laboratory features of a new syndrome. AMA J Dis Child 1959;97:387-408. PMID 13636694
  4. Baehner, RL, Nathan, DG. Leukocyte oxidase: a defective activity in chronic granulomatous disease. Science 1967; 155:835. PMID 6018195.
  5. 5.0 5.1 Winkelstein J, Marino M, Johnston R; et al. (2000). "Chronic granulomatous disease. Report on a national registry of 368 patients.". Medicine (Baltimore). 79 (3): 155–69. PMID 10844935. 
  6. Heyworth P, Curnutte J, Rae J, Noack D, Roos D, van Koppen E, Cross A. "Hematologically important mutations: X-linked chronic granulomatous disease (second update).". Blood Cells Mol Dis. 27 (1): 16–26. PMID 11162142. 
  7. Cross A, Noack D, Rae J, Curnutte J, Heyworth P (2000). "Hematologically important mutations: the autosomal recessive forms of chronic granulomatous disease (first update).". Blood Cells Mol Dis. 26 (5): 561–5. PMID 11112388. 
  8. Kasper, DL, Fauci, AS, Longo, DL, Braunwald, E, Hauser, SL, and Jameson, JL. Harrison's Principles of Internal Medicine, 16th edition 2005;357. ISBN 0-07-139140-1.
  9. Weening R, Kabel P, Pijman P, Roos D (1983). "Continuous therapy with sulfamethoxazole-trimethoprim in patients with chronic granulomatous disease.". J Pediatr. 103 (1): 127–30. PMID 6408232. 
  10. Cale C, Jones A, Goldblatt D (2000). "Follow up of patients with chronic granulomatous disease diagnosed since 1990.". Clin Exp Immunol. 120 (2): 351–5. PMID 10792387. 
  11. Sabo J, Abdel-Rahman S (2000). "Voriconazole: a new triazole antifungal.". Ann Pharmacother. 34 (9): 1032–43. PMID 10981251. 
  12. "A controlled trial of interferon gamma to prevent infection in chronic granulomatous disease. The International Chronic Granulomatous Disease Cooperative Study Group.". N Engl J Med. 324 (8): 509–16. 1991. PMID 1846940. 
  13. Dinauer M, Gifford M, Pech N, Li L, Emshwiller P (2001). "Variable correction of host defense following gene transfer and bone marrow transplantation in murine X-linked chronic granulomatous disease.". Blood. 97 (12): 3738–45. PMID 11389011. 
  14. Ott M, Schmidt M, Schwarzwaelder K; et al. (2006). "Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.". Nat Med. 12 (4): 401–9. PMID 16582916. 

External links

nl:Chronische granulomateuze ziekte


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