Cancer research

Jump to: navigation, search

WikiDoc Resources for Cancer research

Articles

Most recent articles on Cancer research

Most cited articles on Cancer research

Review articles on Cancer research

Articles on Cancer research in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Cancer research

Images of Cancer research

Photos of Cancer research

Podcasts & MP3s on Cancer research

Videos on Cancer research

Evidence Based Medicine

Cochrane Collaboration on Cancer research

Bandolier on Cancer research

TRIP on Cancer research

Clinical Trials

Ongoing Trials on Cancer research at Clinical Trials.gov

Trial results on Cancer research

Clinical Trials on Cancer research at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Cancer research

NICE Guidance on Cancer research

NHS PRODIGY Guidance

FDA on Cancer research

CDC on Cancer research

Books

Books on Cancer research

News

Cancer research in the news

Be alerted to news on Cancer research

News trends on Cancer research

Commentary

Blogs on Cancer research

Definitions

Definitions of Cancer research

Patient Resources / Community

Patient resources on Cancer research

Discussion groups on Cancer research

Patient Handouts on Cancer research

Directions to Hospitals Treating Cancer research

Risk calculators and risk factors for Cancer research

Healthcare Provider Resources

Symptoms of Cancer research

Causes & Risk Factors for Cancer research

Diagnostic studies for Cancer research

Treatment of Cancer research

Continuing Medical Education (CME)

CME Programs on Cancer research

International

Cancer research en Espanol

Cancer research en Francais

Business

Cancer research in the Marketplace

Patents on Cancer research

Experimental / Informatics

List of terms related to Cancer research

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Cancer research is research into cancer in order to identify causes and develop strategies for prevention, diagnosis, treatments and cure.

Cancer research ranges from epidemiology, molecular bioscience (bench research) to the performance of clinical trials to evaluate and compare applications of the various cancer treatment. These applications include surgery, radiation therapy, chemotherapy and hormone therapy, and combined treatment modalities such as chemo-radiotherapy. Starting in the mid-1990s, the emphasis in clinical cancer research shifted towards therapies derived from biotechnology research, such as immunotherapy and gene therapy.

Areas of research

Cause

This type of research involves many different disciplines including genetics, diet, environmental factors (i.e., chemical carcinogens).

Genes involved in cancer

As the Cancer Genome Project stated in a 2004 review article, "a central aim of cancer research has been to identify the mutated genes that are causally implicated in oncogenesis (cancer genes)."[1]

Several hereditary factors can increase the chance of cancer-causing mutations, including the activation of oncogenes or the inhibition of tumor suppressor genes. The functions of various onco- and tumor suppressor genes can be disrupted at different stages of tumor progression. Mutations in such genes can be used to classify the malignancy of a tumor.

In later stages, tumors can develop a resistance to cancer treatment. The identification of oncogenes and tumor suppressor genes is important to understand tumor progression and treatment success.

Genes and protein products that have been identified by at least two independent publications as being involved in cancer are: ABI1, ABL2, ACSL6, AF1Q, AF5Q31 (also known as MCEF), AKT1, ARNT, ASPSCR1, ATF1, ATIC, BCL10, BFHD, BIRC3, BMPR1A, BTG1, CBFA2T1, CBFA2T3, CBFB, CCND1, CDC2, CDK4, CHIC2, CHN1, COPEB, COX6C, CTNNB1, CYLD, DDB2, DDIT3, DEK, EIF4A2, EPS15, ERCC2, ERCC3, ERCC5, ERG, ETV4, ETV6, EWSR1, EXT1, EXT2, FANCC, FANCG, FGFR1OP, FGFR3, FH, FIP1L1, FUS, GAS7, GATA1, GMPS, GOLGA5, GPC, GPHN, HIST1H4I, HRAS, HSPCA, IL21R, IRF4, KRAS2, LASP1, LCP1, LHFP, LMO2, LYL1, MADH4, MLF1, MLH1, MLLT3, MLLT6, MNAT1, MSF, MSH2, MSN, MUTYH, MYC, NCOA4, NF2, NPM1, NRAS, PAX8, PCBD, PDGFB, PIM1, PLK2, PNUTL1, POU2F1, PPARG, PRCC, PRKACB, PRKAR1A, PTEN, PTPN11, RABEP1, RAD51L1, RAP1GDS1, RARA, RB1, RET, RHOH, RPL22, SBDS, SDHB, SEPTIN6, SET, SH3GL1, SS18L1, SSX1, SSX2, SSX4, STAT3, TAF15, TCF12, TCL1A, TFE3, TFEB, TFG, TFPT, TFRC, TNFRSF6, TP53, TPM3, TPM4, TRIP11, VHL, WAS, WT1, ZNF198, ZNF278, ZNF384, ZNFN1A1 Based on a study by M. R Straton and co-workers " A census of human cancer genes".

Treatment

Current topics of cancer treatment research include:

Specific treatment research topics

Dichloroacetate

In January 2007 researchers of the University of Alberta reported preliminary results of dichloroacetate (DCA) causing regression in several cancers in vitro, including lung, breast and brain tumors.[3] Since the compound DCA itself cannot be patented it could be an inexpensive alternative to other treatments, depending of course on whether the method of using DCA in the treatment of cancer is patentable. Clinical use of DCA will of course require further public/private investment for clinical trials.[4] The initial research was funded by the Canadian Institutes of Health Research.[5]

Prevention

  • Vaccines (see HPV Vaccine)
  • Recent research may indicate a connection between Vitamin D deficiency and cancer.[6]

Funding

Some methods, like Dichloroacetate, cannot be patented and thus would not garner the investment interest towards research from the pharmaceutical industry.[4]

Stemcell research

Clinical trials

Organizations

Related chapters

REsources

References

  1. Futreal PA, Coin L, Marshall M, Down T, Hubbard T, Wooster R, Rahman, N, Stratton MR (2004). "A census of human cancer genes". Nature Reviews Cancer. 4: 177–83. PMID 14993899. 
  2. "Gene Therapy, Cancer-Killing Viruses And New Drugs Highlight Novel Approaches To Cancer Treatment". Medical News Today. Retrieved April 24. 
  3. Alberta scientists test chemotherapy alternative. Last Updated Wednesday, January 17, 2007
  4. 4.0 4.1 "Cheap, safe drug kills most cancers". New Scientist. 2007-01-17. Retrieved 2007-01-17. 
  5. University of Alberta - Small molecule offers big hope against cancer. January 16, 2007
  6. "Vitamin D casts cancer prevention in new light". Globe and Mail. 2007-04-28. Retrieved 2007-04-29. 
nl:Kankeronderzoek



Linked-in.jpg