Calcitonin gene-related peptide receptor

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calcitonin receptor-like receptor
Identifiers
SymbolCALCRL
Entrez10203
HUGO16709
OMIM114190
RefSeqNM_005795
UniProtQ16602
Other data
LocusChr. 2 q21.1-21.3

The calcitonin gene-related peptide receptors consist of a 7-transmembrane G-protein coupled, calcitonin receptor-like receptor (CL) linked to one of three single transmembrane domain receptor activity-modifying proteins (RAMPs) that are essential for functional activity.

The association of CL with different RAMP proteins produces different receptors:

These receptors are linked to adenylate cyclase and activation results in the generation of intracellular cyclic adenosine monophosphate (cAMP).

External links


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