CYP3A7

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External IDsGeneCards: [1]
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CYP3A7 is an enzyme belonging to the cytochrome P450 family. It is 503 amino acids in size and shares 87% of its sequence with CYP3A4. It carries out a similar role in fetuses that CYP3A4 serves in adults.[1] The gene location is 7q22.1.[2]

The CYP3A group of enzymes are the most abundantly expressed members of the cytochrome P450 family in liver. They are responsible for the metabolism of more than 50% of all clinical pharmaceuticals.[3]

Notable alleles

The CYP3A7*1C allele is associated with poor outcomes in some cancer patients, possibly because of the effect of the enzyme on some chemotherapy agents.[4]

References

  1. Komori M, Nishio K, Ohi H, Kitada M, Kamataki T (February 1989). "Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450". J. Biochem. 105 (2): 161–3. PMID 2722762.
  2. "Cytochrome P450, Subfamily IIIA, Polypeptide 7". OMIM. Retrieved March 14, 2013.
  3. Paulussen A, Lavrijsen K, Bohets H, Hendrickx J, Verhasselt P, Luyten W, Konings F, Armstrong M (July 2000). "Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans". Pharmacogenetics. 10 (5): 415–24. doi:10.1097/00008571-200007000-00005. PMID 10898111.
  4. CYP3A7*1C Allele Associated With Poor Outcomes in CLL, Breast, and Lung Cancer

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