CEACAM3

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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Carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) also known as CD66d (Cluster of Differentiation 66d), is a member of the carcinoembryonic antigen (CEA) gene family..[1]

This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[1]

Use

CEACAM3 is expressed exclusively on granulocytes and used as granulocyte marker.[2]

See also

References

  1. 1.0 1.1 "Entrez Gene: CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3".
  2. CEACAM3: an innate immune receptor directed against human-restricted bacterial pathogens. Pils S, Gerrard DT, Meyer A, Hauck CR. Int J Med Microbiol. 2008 Oct;298(7-8):553-60.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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