CD32

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Fc fragment of IgG, low affinity IIa, receptor (CD32)
Identifiers
SymbolFCGR2A
Alt. symbolsFCG2, FCGR2A1, FCGR2
Entrez2212
HUGO3616
OMIM146790
RefSeqNM_021642
UniProtP12318
Other data
LocusChr. 1 q23
Fc fragment of IgG, low affinity IIb, receptor (CD32)
File:CD32ray.png
Crystal structure of the human fcgamma-receptor IIb ectodomain (CD32).[1]
Identifiers
SymbolFCGR2B
Alt. symbolsFCG2, FCGR2
Entrez2213
HUGO3618
OMIM604590
RefSeqNM_004001
UniProtP31994
Other data
LocusChr. 1 q23
Fc fragment of IgG, low affinity IIc, receptor for (CD32)
Identifiers
SymbolFCGR2C
Entrez9103
HUGO15626
RefSeqNM_201563
UniProtP31995
Other data
LocusChr. 1 q23

CD32 is a surface receptor protein and part of a large population of B cell co-receptors, which act to modulate signaling.

It has a low-affinity for IgG antibodies and down-regulates antibody production in the presence of IgG. This feedback loop acts to lower the production of IgG by B cells when there is a surplus in the body. Monoclonal antibodies can distinguish between CD32A and CD32B.[2]

References

  1. PDB: 2FCB​; Sondermann P, Huber R, Jacob U (March 1999). "Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution". EMBO J. 18 (5): 1095–103. doi:10.1093/emboj/18.5.1095. PMC 1171201. PMID 10064577.; rendered via PyMOL.
  2. Veri MC, Gorlatov S, Li H, et al. (2007). "Monoclonal antibodies capable of discriminating the human inhibitory Fcgamma-receptor IIB (CD32B) from the activating Fcgamma-receptor IIA (CD32A): biochemical, biological and functional characterization". Immunology. 121 (3): 392–404. doi:10.1111/j.1365-2567.2007.02588.x. PMC 2265948. PMID 17386079.

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