CD276

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VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

CD276 (Cluster of Differentiation 276) is a human protein encoded by the CD276 gene.[1]

Function

Costimulatory B7 molecules (e.g., B7-1, or CD80; MIM 112203) signal through CD28 (MIM 186760) family molecules such as CD28, CTLA4 (MIM 123890), and ICOS (MIM 604558).[supplied by OMIM][1]

CD276 (aka B7-H3), an immune checkpoint molecule, is expressed by some solid tumours and is the target of anticancer candidates such as MGA271.[2]

See also

References

  1. 1.0 1.1 "Entrez Gene: CD276 CD276 molecule".
  2. "Servier Pays MacroGenics $20M for Option to Anticancer Antibody - GEN". GEN.

Further reading

External links


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