CD15

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fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
Identifiers
SymbolFUT4
Alt. symbolsCD15, FCT3A, ELFT
Entrez2526
HUGO4015
OMIM104230
RefSeqNM_002033
UniProtP22083
Other data
LocusChr. 11 q21

CD15 (3-fucosyl-N-acetyl-lactosamine) is a cluster of differentiation - an immunologically significant molecule. CD15 is a carbohydrate adhesion molecule (not a protein) that mediates phagocytosis and chemotaxis, found on neutrophils; expressed in patients with Hodgkin disease, some B-cell chronic lymphocytic leukemias, acute lymphoblastic leukemias, and most acute nonlymphocytic leukemias. It is also called Lewis x and SSEA-1 (stage specific embryonic antigen 1) and represents a marker for murine pluripotent stem cells, in which it plays an important role in adhesion and migration of the cells in the preimplantation embryo. It is synthezised by FUT 4 (fucosyltransferase 4).

See also



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