CCL7

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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Chemokine (C-C motif) ligand 7 (CCL7) is a small cytokine known as a chemokine that was previously called monocyte-chemotactic protein 3 (MCP3). Due to CCL7 possessing two adjacent N-terminal cysteine residues in its mature protein, it is classified among the subfamily of chemokines known as CC chemokines. CCL7 specifically attracts monocytes, and regulates macrophage function[citation needed]. It is produced by certain tumor cell lines and by macrophages.[1] This chemokine is located on chromosome 17 in humans, in a large cluster containing many other CC chemokines[2] and is most closely related to CCL2 (previously called MCP1).

Interactions

CCL7 has been shown to interact with MMP2.[3] It bind to the CCR2 receptor.

References

  1. Opdenakker G, Froyen G, Fiten P, Proost P, Van Damme J (1993). "Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines". Biochem. Biophys. Res. Commun. 191 (2): 535–42. doi:10.1006/bbrc.1993.1251. PMID 8461011.
  2. Opdenakker G, Fiten P, Nys G, Froyen G, Van Roy N, Speleman F, Laureys G, Van Damme J (1994). "The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12". Genomics. 21 (2): 403–8. doi:10.1006/geno.1994.1283. PMID 7916328.
  3. McQuibban, G A; Gong J H; Tam E M; McCulloch C A; Clark-Lewis I; Overall C M (August 2000). "Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3". Science. UNITED STATES. 289 (5482): 1202–6. Bibcode:2000Sci...289.1202M. doi:10.1126/science.289.5482.1202. ISSN 0036-8075. PMID 10947989.

External links

Further reading




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