CCL26

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chemokine (C-C motif) ligand 26
Identifiers
SymbolCCL26
Alt. symbolsSCYA26, MIP-4alpha, eotaxin-3, IMAC, MIP-4a, TSC-1
Entrez10344
HUGO10625
OMIM604697
PDB1G2T
RefSeqNM_006072
UniProtQ9Y258
Other data
LocusChr. 7 q11.2

Chemokine (C-C motif) ligand 26 (CCL26) is a small cytokine belonging to the CC chemokine family that is also called Eotaxin-3, Macrophage inflammatory protein 4-alpha (MIP-4-alpha), Thymic stroma chemokine-1 (TSC-1), and IMAC. It is expressed by several tissues including heart, lung and ovary, and in endothelial cells that have been stimulated with the cytokine interleukin 4.[1][2] CCL26 is chemotactic for eosinophils and basophils and elicits its effects by binding to the cell surface chemokine receptor CCR3.[3] This gene for chemokine is located on human chromosome 7.[4]

References

  1. Shinkai et al. A novel human CC chemokine, eotaxin-3, which is expressed in IL-4-stimulated vascular endothelial cells, exhibits potent activity toward eosinophils. J. Immunol. 163:1602-1610, 1999.
  2. Guo et al. Molecular cloning and characterization of a novel human CC chemokine, SCYA26. Genomics 58:313-317, 1999.
  3. Kitaura et al. Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3. J. Biol. Chem. 274:27975-27980, 1999.
  4. Hillier et al. The DNA sequence of human chromosome 7. Nature 424:157-164, 2003.

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