CCL21

Jump to: navigation, search
VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Chemokine (C-C motif) ligand 21 (CCL21) is a small cytokine belonging to the CC chemokine family. This chemokine is also known as 6Ckine (because it has six conserved cysteine residues instead of the four cysteines typical to chemokines), exodus-2, and secondary lymphoid-tissue chemokine (SLC).[1][2][3] The gene for CCL21 is located on human chromosome 9. CCL21 elicits its effects by binding to a cell surface chemokine receptor known as CCR7.[4]

In human lymph nodes, the fibroblastic reticular cells (FRCs) express CCL21 as a chemoattractant to guide naive, CCR7 expressing T cells to the T cell zone. [5][6]

References

  1. Hedrick JA, Zlotnik A (August 1997). "Identification and characterization of a novel beta chemokine containing six conserved cysteines". Journal of Immunology. 159 (4): 1589–93. PMID 9257816.
  2. Hromas R, Kim CH, Klemsz M, Krathwohl M, Fife K, Cooper S, Schnizlein-Bick C, Broxmeyer HE (September 1997). "Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension". Journal of Immunology. 159 (6): 2554–8. PMID 9300671.
  3. Nagira M, Imai T, Hieshima K, Kusuda J, Ridanpää M, Takagi S, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O (August 1997). "Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13". The Journal of Biological Chemistry. 272 (31): 19518–24. doi:10.1074/jbc.272.31.19518. PMID 9235955.
  4. Yoshida R, Nagira M, Kitaura M, Imagawa N, Imai T, Yoshie O (March 1998). "Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7". The Journal of Biological Chemistry. 273 (12): 7118–22. doi:10.1074/jbc.273.12.7118. PMID 9507024.
  5. Mueller SN, Germain RN (September 2009). "Stromal cell contributions to the homeostasis and functionality of the immune system". Nature Reviews. Immunology. 9 (9): 618–29. doi:10.1038/nri2588. PMID 19644499.
  6. Mueller SN, Germain RN (September 2009). "Stromal cell contributions to the homeostasis and functionality of the immune system". Nature Reviews. Immunology. 9 (9): 618–29. doi:10.1038/nri2588. PMC 2785037. PMID 19644499.

External links

Further reading


Linked-in.jpg