CCL17

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Chemokine (C-C motif) ligand 17 (CCL17) (also known as TARC) is a small cytokine belonging to the CC chemokine family is also known as thymus and activation regulated chemokine (TARC). CCL17 is expressed constitutively in thymus, but only transiently in phytohemagglutinin-stimulated peripheral blood mononuclear cells.[1] This chemokine specifically binds and induces chemotaxis in T cells and elicits its effects by interacting with the chemokine receptor CCR4.[1][2] The gene for CCL17 is located on chromosome 16, in humans, along with other chemokines called CCL22 and CX3CL1.[3][4]

References

  1. 1.0 1.1 Imai T, Yoshida T, Baba M, Nishimura M, Kakizaki M, Yoshie O (1996). "Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector". J. Biol. Chem. 271 (35): 21514–21. doi:10.1074/jbc.271.35.21514. PMID 8702936.
  2. Imai T, Baba M, Nishimura M, Kakizaki M, Takagi S, Yoshie O (1997). "The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4". J. Biol. Chem. 272 (23): 15036–42. doi:10.1074/jbc.272.23.15036. PMID 9169480.
  3. Nomiyama H, Imai T, Kusuda J, Miura R, Callen DF, Yoshie O (1997). "Assignment of the human CC chemokine gene TARC (SCYA17) to chromosome 16q13". Genomics. 40 (1): 211–3. doi:10.1006/geno.1996.4552. PMID 9070951.
  4. Nomiyama H, Imai T, Kusuda J, Miura R, Callen DF, Yoshie O (1998). "Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13". Cytogenet. Cell Genet. 81 (1): 10–1. doi:10.1159/000015000. PMID 9691168.

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