C8 complex

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File:3OJY.png
High Resolution Crystal Structure of Human Complement Component 8
complement component 8, alpha polypeptide
Identifiers
SymbolC8A
Entrez731
HUGO1352
OMIM120950
RefSeqNM_000562
UniProtP07357
Other data
LocusChr. 1 p36.2-22.1
complement component 8, beta polypeptide
Identifiers
SymbolC8B
Entrez732
HUGO1353
OMIM1209660
RefSeqNM_000066
UniProtP073o58
Other data
LocusChr. 1 p36.2-22.1
complement component 8, gamma polypeptide
Identifiers
SymbolC8G
Entrez733
HUGO1354
OMIM120930
RefSeqNM_000606
UniProtP07360
Other data
LocusChr. 9 q34.3

Complement component 8 is a protein involved in the complement system. It is part of the membrane attack complex (MAC).

A hereditary deficiency of C8 can result in increased susceptibility to Neisseria infections, such as meningitis and gonorrhea.

File:Formowanie MAC.svg

Structure

C8 is a heterotrimer; it consists of three different subunits. These are called C8 alpha, beta and gamma chains, encoded by the genes C8A, C8B and C8G respectively.

References

1.J Biol Chem. 2011 May 20;286(20):17585-92. Epub 2011 Mar 25. Figure created in Pymol

External links

The crystal structure is now in the PDB, PDB ID 3OJY.



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