C3 (complement)

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complement component 3
Identifiers
Symbol C3
Entrez 718
HUGO 1318
OMIM 120700
RefSeq NM_000064
UniProt P01024
Other data
EC number 3.4.21.43
Locus Chr. 19 p13.3-13.2

In immunology, soluble C3-convertase, also known as iC3Bb, catalyzes the proteolytic cleavage of C3 into C3a and C3b as part of the alternative complement system.

C3a

C3a plays an important role in chemotaxis, though not as important a role as C5a.[1]

It is also an anaphylatoxin.

C3b

C3b may bind to microbial cell surfaces within an organism's body. This can lead to the production of surface-bound C3 convertase and thus more C3b components. Also known as C3bBb, this convertase is similar to soluble C3-convertase except that it is membrane bound.

Alternatively, bound C3b may aid in opsonization of the microbe by macrophages.[1] Complement receptor 1 or CR1 on macrophages allows the engaging of C3b covered microbes.

C3b is cleaved into C3c and C3d.

See also

References

External links

  • Sahu A, Lambris J (2001). "Structure and biology of complement protein C3, a connecting link between innate and acquired immunity". Immunol Rev. 180: 35–48. PMID 11414361. 
  • Fredslund F, Jenner L, Husted L, Nyborg J, Andersen G, Sottrup-Jensen L (2006). "The structure of bovine complement component 3 reveals the basis for thioester function". J Mol Biol. 361 (1): 115–27. PMID 16831446. 
  • PDB 2B39, PDB 2A73
  • domain structure; protein database
  • MeSH Complement+C3



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