complement component 3
|Locus||Chr. 19 p13.3-13.2|
It is also an anaphylatoxin.
C3b may bind to microbial cell surfaces within an organism's body. This can lead to the production of surface-bound C3 convertase and thus more C3b components. Also known as C3bBb, this convertase is similar to soluble C3-convertase except that it is membrane bound.
C3b is cleaved into C3c and C3d.
- Sahu A, Lambris J (2001). "Structure and biology of complement protein C3, a connecting link between innate and acquired immunity". Immunol Rev. 180: 35–48. PMID 11414361.
- Fredslund F, Jenner L, Husted L, Nyborg J, Andersen G, Sottrup-Jensen L (2006). "The structure of bovine complement component 3 reveals the basis for thioester function". J Mol Biol. 361 (1): 115–27. PMID 16831446.
- PDB 2B39, PDB 2A73
- domain structure; protein database
- MeSH Complement+C3