|Chromosome 1 open reading frame 127|
|Ideogram human chromosome 1|
Uncharactarized protein C1orf127 is a protein that in humans is encoded by the C1orf127 gene, the structure and function of which is poorly understood by the scientific community. C1orf127 is targeted for extracellular secretion in humans.
C1orf127’s protein product is a member of the Ensembl protein family TF607005. The primary assembly weighs 89 kDa with an isoelectric point of 5.54, making it both longer and heavier than the average protein.
Domains and Motifs
C1orf127 is contains two protein domains: DUF4556 and PHA03247, a domain in the Atrophin-1 superfamily. The functions of both domains are unknown. The protein also appears to have a cleavable signal peptide from Met1 to Pro18.
The protein C1orf127 is suggested to be localized to the extracellular matrix in humans.
C1orf127 is suggested to interact with two different proteins, CCT3, a molecular chaperone, and CCT6B, also a molecular chaperone found in the testis. Because these interacting proteins are both molecular chaperones, it is possible that C1orf127 must undergo chaperone-assisted folding or unfolding.
C1orf127 is not constitutively expressed, but it is expressed at low to medium levels in a variety of tissues. Greatest expression is observed in the stomach and pancreas. It is also thought to be expressed in certain areas of both the developing and adult brain, such as the cerebellum, as well as skeletal muscle tissue, the testis, cardiac muscle, and throughout the digestive system.
Little else is known about this gene’s expression, however a 2012 paper published in the World Journal of Gastroenterology suggested that it’s mis-expression could be used as a diagnostic marker locus in the detection of cancer
C1orf127 has no paralogs within the human genome, however a number of orthologs have been identified, ranging across the jawed vertebrates, including a number of other mammals, marsupials, amphibians, and fish. One of the most distant ortholog identified is found in Danio rerio. Thus, the ancestor of C1orf127 likely arose around 435 MYA.
|Species||NCBI Accession Number||Sequence Length||Identity to Human|
|Saimiri boliviensis boliviensis||XP_010344835.1||817||79%|
- "C1orf127 chromosome 1 open reading frame 127 [ Homo sapiens (human) ]". National Center for Biotechnology Information. Retrieved 18 February 2018.
- "Gene: C1orf127". Ensembl. Retrieved 19 February 2018.
- Lodish H, Berk A, Matsudaira P, Kaiser CA, Krieger M, Scott MP, Zipurksy SL, Darnell J (2004). Molecular Cell Biology (5th ed.). New York, New York: WH Freeman and Company.
- "Conserved domains on uncharacterized protein precursor C1orf127". National Center for Biotechnology Information.
- "PSORT II". PSORT II Prediction. Retrieved 6 May 2018.
- "C1orf127 chromosome open reading frame 127 [Homo sapiens (human)]". Retrieved 19 February 2018.
- Liu, Yuan-Yuan; Chen, Hai-Ying; Zhang, Man-Li; Tian, Dan; Li, Shibo; Lee, Ji-Yun (September 7, 2012). "Loss of fragile histidine triad and amplification of 1p36.22 and 11p15.5 in primary gastric adenocarcinomas". World Journal of Gastroenterology. 18 (33): 4522–4532. doi:10.3748/wjg.v18.i33.4522. PMC 3435777.