Butyrate-CoA ligase

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In enzymology, a butyrate-CoA ligase (EC is an enzyme that catalyzes the chemical reaction

ATP + an acid + CoA AMP + diphosphate + an acyl-CoA

The 3 substrates of this enzyme are ATP, acid, and CoA, whereas its 3 products are AMP, diphosphate, and acyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is butanoate:CoA ligase (AMP-forming). Other names in common use include butyryl-CoA synthetase, fatty acid thiokinase (medium chain), acyl-activating enzyme, fatty acid elongase, fatty acid activating enzyme, fatty acyl coenzyme A synthetase, medium chain acyl-CoA synthetase, butyryl-coenzyme A synthetase, L-(+)-3-hydroxybutyryl CoA ligase, and short-chain acyl-CoA synthetase. This enzyme participates in butanoate metabolism.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
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  • Google Scholar references for
  • MAHLER HR, WAKIL SJ, BOCK RM (1953). "Studies on fatty acid oxidation. I. Enzymatic activation of fatty acids". J. Biol. Chem. 204: 453&ndash, 68. PMID 13084616.
  • Massaro EJ and Lennarz WJ (1965). "The partial purification and characterization of a bacterial fatty acyl coenzyme A synthetase". Biochemistry. 4: 85&ndash, 90.
  • Websterlt JR, Gerowin LD and Rakita L (1965). "Purification and characteristics of a butyryl coenzyme A synthetase from bovine heart mitochondria". J. Biol. Chem. 240: 29&ndash, 33.

External links

The CAS registry number for this enzyme class is 9080-51-7.

Gene Ontology (GO) codes