Bowen's disease

Jump to: navigation, search
Bowen's disease
Bowens.jpg
ICD-10 D00-D09
ICD-9 230-234
DiseasesDB 1569

Bowen's disease Microchapters

Overview

Historical Perspective

Pathophysiology

Causes

Epidemiology and Demographics

Natural History, Complications and Prognosis

Diagnosis

Treatment

Prevention

Differentiating Bowen's disease from other Diseases

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sara Mohsin, M.B.B.S.[2] Jesus Rosario Hernandez, M.D. [3]

Synonyms and Keywords: Bowen's carcinoma; squamous cell carcinoma in situ of skin; intraepidermal carcinoma skin, Intraepithelial neoplasia

Overview

In medicine (dermatology), Bowen's disease (BD) is a sunlight-induced skin disease, classified either as an early noninvasive stage or intraepidermal form of squamous cell carcinoma which if left undiagnosed, untreated, or neglected has <10% chance of malignant transformation into invasive squamous cell carcinoma of the skin. It usually appears as a erythematous, scaly or crusty patch or plaque anywhere on the body but most commonly involves lower legs, with other possible sites of involvement to be head, neck, genitals, and skin folds. It is easily curable by various treatment options such as cryotherapy, curettage, cautery, photodynamic therapy, topical chemotherapy, radiotherapy, or excision of the lesion.

Historical Perspective

  • In 1912, Dr John T. Bowen was the first one to describe this disease, hence, it is named after him

Pathophysiology

Microscopic Pathology

Borst-Jadassohn phenomenon

H & E stain ofBowen's disease as seen under a microscope [https://commons.wikimedia.org/wiki/Category:Histopathology_of_Bowen%27s_disease#/media/File:Bowen_disease_(2).jpg Source: Wikimedia Commons
Histopathology of squamous cell carcinoma in situ of the skin (Bowen disease). H & E stain [https://commons.wikimedia.org/wiki/Category:Histopathology_of_Bowen%27s_disease#/media/File:Bowen_disease_(3).jpg Source: Wikimedia Commons
Bowen's disease as seen under a microscope
Histopathology of squamous cell carcinoma in situ of the skin (Bowen disease). H & E stain [https://commons.wikimedia.org/wiki/Category:Histopathology_of_Bowen%27s_disease#/media/File:Bowen_disease_(4).jpg Source: Wikimedia Commons
SCCIS from sundamaged skin. Pagetoid SCCIS on the left, conventional SCCIS on the right. [https://commons.wikimedia.org/wiki/Category:Histopathology_of_Bowen%27s_disease#/media/File:Skin_SCCIS_PagetoidandConventional_15BR30103.jpg Source: Wikimedia Commons

Causes

Bowen's disease is a non-infectious, non-familial disease with common causes as mentioned below:

Epidemiology and Demographics

Age

Gender

Race

Natural History, Complications and Prognosis

Diagnosis

Common symptoms

Signs and symptoms of malignant transformation

Common sites of involvement

Skin

Extremities

Head and neck area

Subungal, periungal region

Skinfolds

Genitourinary system

Multiple forms of Bowen's disease involving genital region
Bowen's disease form Characteristic features
Bowenoid papulosis
Erythroplasia of Queyrat
Vulvar intraepithelial neoplasia (VIN)


Physical Examination

Bowen's disease

Dermoscopy

Skin biopsy

Treatment

Different treatment options for Bowen's disease
Treatment option Details
Watch and wait
Cryosurgery/Freezing
Topical cream
Curettage & electrodesiccation or cryotherapy
Cauterization or diathermy coagulation[28]
Photodynamic therapy (PDT)[29][30][31][32][33][34]
Radiation therapy[35][36][37][38][39][40]
Excision
Mohs micrographic surgery

Prevention

Following are the few preventive measures to lower the risk for developing Bowen's disease:

Primary preventive measures for Bowen's disease
Preventive method Details
Avoiding sunburns and suntans
Wearing protective clothing Wear the following while being in the outdoor environment:
Wearing SPF sunscreen
Avoiding tanning beds
Being aware of sun-sensitizing medications
Checking skin regularly and reporting any new or unusual skin changes to the doctor
Reducing the exposure to ultraviolet (UV) radiation, especially during the early years of life

Differentiating Bowen's disease from other Diseases

Differentiating Bowen's disease from other diseases
Disease entity Etiology Pathophysiology Common sites of involvement Clinical manifestations Images
Bowen's disease Common causes include: Histopathology shows:


Most commonly involves:
Bowen's disease
Psoriasis Histopathology shows: Involves:
A young man whose back and arms are affected by psoriasis, source: wikipedia.org
Eczema Common causes include: Involves:
Typical, mild dermatitis
Superficial basal cell carcinoma Common causes include:
Kelly Nelson (Photographer) [Public domain], via Wikimedia Commons,https://upload.wikimedia.org/wikipedia/commons/3/32/Basal_cell_carcinoma%2C_superficial.jpg
Actinic keratosis Can involve any sun-exposed area such as:
Seborrheic keratosis Involves:
Lichen planus Causes include: Involves:
Lichen planus
Tinea corporis
This patient presented with ringworm on the arm, or tinea corporis due to Trichophyton mentagrophytes.
Extramammary Paget’s disease[41][42][43][44][45][46][47][48][49][50][51][52][53][54] Most common cause is the underlying malignancy such as: Frequently occurs in areas of abundance of apocrine sweat glands such as:

[[File:Extramammary Paget's Disease.png|thumb|200px|none|Extramammary paget's disease [Source: Wikimedia Commons]]

References

  1. Neagu TP, Tiglis M, Botezatu D, Enache V, Cobilinschi CO, Vâlcea-Precup MS, GrinTescu IM (2017). "Clinical, histological and therapeutic features of Bowen's disease". Rom J Morphol Embryol. 58 (1): 33–40. PMID 28523295.
  2. Nemkaeva RM, Kurmashov NA, Oslopova S (1988). "[Bowen's disease]". Vestn Dermatol Venerol (8): 71–2. PMID 3195216.
  3. Scarborough DA, Bisaccia EP, Yoder FW (1982). "Solitary pigmented Bowen's disease". Arch Dermatol. 118 (11): 954–5. PMID 7138058.
  4. Yanagihara S, Oiso N, Hirota N, Kato M, Miyake S, Kawada A (2019). "Acantholytic Bowen's disease histopathologically showing the Borst-Jadassohn phenomenon". Eur J Dermatol. doi:10.1684/ejd.2019.3545. PMID 31145080.
  5. Baykal C, Buyukbabani N, Babuna G, Polat Ekinci A, Kurul S (2016). "Giant Bowen's disease histologically showing Borst-Jadassohn phenomenon and complicated with squamous cell carcinoma development". J Eur Acad Dermatol Venereol. 30 (10): e88–e89. doi:10.1111/jdv.13335. PMID 26373350.
  6. "Borst-Jadassohn phenomenon | definition of Borst-Jadassohn phenomenon by Medical dictionary".
  7. "Pathology Outlines - Borst-Jadassohn phenomenon".
  8. "PayPerView: Jadassohn's Intraepidermal Epithelioma - Karger Publishers".
  9. Lora V, Chouvet B, Kanitakis J (2011). "The "intraepidermal epithelioma" revisited: immunohistochemical study of the borst-jadassohn phenomenon". Am J Dermatopathol. 33 (5): 492–7. doi:10.1097/DAD.0b013e3181fe6f90. PMID 21587033.
  10. Clavel CE, Huu VP, Durlach AP, Birembaut PL, Bernard PM, Derancourt CG (1999). "Mucosal oncogenic human papillomaviruses and extragenital Bowen disease". Cancer. 86 (2): 282–7. PMID 10421264.
  11. Zheng S, Adachi A, Shimizu M, Shibata SI, Yasue S, Sakakibara A; et al. (2005). "Human papillomaviruses of the mucosal type are present in some cases of extragenital Bowen's disease". Br J Dermatol. 152 (6): 1243–7. doi:10.1111/j.1365-2133.2005.06643.x. PMID 15948988.
  12. Lampert A, Pauwels C, Duboucher C, Morel G, Poveda JD, Périé G (2000). "[Detection of human papillomavirus in cutaneous extragenital Bowen's disease in immunocompetent patients]". Ann Dermatol Venereol. 127 (1): 40–5. PMID 10717561.
  13. Collina G, Rossi E, Bettelli S, Cook MG, Cesinaro AM, Trentini GP (1995). "Detection of human papillomavirus in extragenital Bowen's disease using in situ hybridization and polymerase chain reaction". Am J Dermatopathol. 17 (3): 236–41. PMID 8599431.
  14. Derancourt C, Mougin C, Chopard Lallier M, Coumes-Marquet S, Drobacheff C, Laurent R (2001). "[Oncogenic human papillomaviruses in extra-genital Bowen disease revealed by in situ hybridization]". Ann Dermatol Venereol. 128 (6–7): 715–8. PMID 11460032.
  15. Pham-Huu V, Derancourt C, Clavel C, Durlach A, Birembaut P, Bernard P (1999). "[Oncogenic mucosal human papillomaviruses in Bowen's disease of the hands]". Ann Dermatol Venereol. 126 (11): 808–12. PMID 10612858.
  16. Murao K, Yoshioka R, Kubo Y (2014). "Human papillomavirus infection in Bowen disease: negative p53 expression, not p16(INK4a) overexpression, is correlated with human papillomavirus-associated Bowen disease". J. Dermatol. 41 (10): 878–84. doi:10.1111/1346-8138.12613. PMID 25201325.
  17. 17.0 17.1 "Bowen's disease - NHS".
  18. Wagner RF, Grande DJ (1986). "Solitary pigmented Bowen's disease of the scrotum". J Dermatol Surg Oncol. 12 (10): 1114–5. PMID 3760318.
  19. Al-Dawsari NA, Raslan W, Dawamneh MF (2014). "Pigmented Bowen's disease of the penis and scrotum in a patient with AIDS". Dermatol Online J. 20 (4): 22337. PMID 24746300.
  20. Narahira A, Yanagi T, Kitamura S, Hata H, Shimizu H (2019). "Dermoscopic features of genital pigmented Bowen's disease: Report of a case and review of the published work". J Dermatol. doi:10.1111/1346-8138.14938. PMID 31141219.
  21. "Bowen's Disease: Skin Cancer Linked to HPV Infection".
  22. Inoue T, Kobayashi K, Sawada M, Ishizaki S, Ito H, Fujibayashi M; et al. (2010). "Dermoscopic Features of Pigmented Bowen's Disease in a Japanese Female Mimicking Malignant Melanoma". Dermatol Res Pract. 2010. doi:10.1155/2010/543091. PMC 2929512. PMID 20811602.
  23. Hayashi Y, Tanaka M, Suzaki R, Mori N, Konohana I (2009). "Dermoscopy of Pigmented Bowen's Disease Mimicking Early Superficial Spreading Melanoma". Case Rep Dermatol. 1 (1): 11–15. doi:10.1159/000227284. PMC 2895203. PMID 20652107.
  24. Yang Y, Lin J, Fang S, Han S, Song Z (2017). "What's new in dermoscopy of Bowen's disease: two new dermoscopic signs and its differential diagnosis". Int J Dermatol. 56 (10): 1022–1025. doi:10.1111/ijd.13734. PMID 28832993.
  25. Zalaudek I, Argenziano G, Leinweber B, Citarella L, Hofmann-Wellenhof R, Malvehy J; et al. (2004). "Dermoscopy of Bowen's disease". Br J Dermatol. 150 (6): 1112–6. doi:10.1111/j.1365-2133.2004.05924.x. PMID 15214896.
  26. Cameron A, Rosendahl C, Tschandl P, Riedl E, Kittler H (2010). "Dermatoscopy of pigmented Bowen's disease". J Am Acad Dermatol. 62 (4): 597–604. doi:10.1016/j.jaad.2009.06.008. PMID 20079953.
  27. "Bowen Disease - NORD (National Organization for Rare Disorders)".
  28. Neubert T, Lehmann P (2008). "Bowen's disease - a review of newer treatment options". Ther Clin Risk Manag. 4 (5): 1085–95. PMC 2621408. PMID 19209288.
  29. Wong TW, Sheu HM, Lee JY, Fletcher RJ (2001). "Photodynamic therapy for Bowen's disease (squamous cell carcinoma in situ) of the digit". Dermatol Surg. 27 (5): 452–6. PMID 11359493.
  30. Britton JE, Goulden V, Stables G, Stringer M, Sheehan-Dare R (2005). "Investigation of the use of the pulsed dye laser in the treatment of Bowen's disease using 5-aminolaevulinic acid phototherapy". Br J Dermatol. 153 (4): 780–4. doi:10.1111/j.1365-2133.2005.06830.x. PMID 16181460.
  31. Kang HK, Yun JH, Son YM, Roh JY, Lee JR (2014). "Photodynamic Therapy for Bowen's Disease of the Vulva Area". Ann Dermatol. 26 (2): 241–5. doi:10.5021/ad.2014.26.2.241. PMC 4037679. PMID 24882981.
  32. Dijkstra AT, Majoie IM, van Dongen JW, van Weelden H, van Vloten WA (2001). "Photodynamic therapy with violet light and topical 6-aminolaevulinic acid in the treatment of actinic keratosis, Bowen's disease and basal cell carcinoma". J Eur Acad Dermatol Venereol. 15 (6): 550–4. PMID 11843215.
  33. Harth Y, Hirshowitz B, Kaplan B (1998). "Modified topical photodynamic therapy of superficial skin tumors, utilizing aminolevulinic acid, penetration enhancers, red light, and hyperthermia". Dermatol Surg. 24 (7): 723–6. PMID 9693665.
  34. de Haas ER, de Vijlder HC, Sterenborg HJ, Neumann HA, Robinson DJ (2008). "Fractionated aminolevulinic acid-photodynamic therapy provides additional evidence for the use of PDT for non-melanoma skin cancer". J Eur Acad Dermatol Venereol. 22 (4): 426–30. doi:10.1111/j.1468-3083.2007.02445.x. PMID 18031503.
  35. Anna Z, John K, Maria T, George K, Ivelina B, Ioanna K; et al. (2012). "The potential role of radiation therapy in Bowen's disease: a review of the current literature". Rev Recent Clin Trials. 7 (1): 42–6. PMID 21864250.
  36. Lukas VanderSpek LA, Pond GR, Wells W, Tsang RW (2005). "Radiation therapy for Bowen's disease of the skin". Int J Radiat Oncol Biol Phys. 63 (2): 505–10. doi:10.1016/j.ijrobp.2005.02.024. PMID 16168842.
  37. Herman JM, Pierce LJ, Sandler HM, Griffith KA, Jabbari S, Hiniker SM; et al. (2008). "Radiotherapy using a water bath in the treatment of Bowen's disease of the digit". Radiother Oncol. 88 (3): 398–402. doi:10.1016/j.radonc.2008.05.025. PMID 18571754.
  38. Goodman CR, DeNittis A (2017). "Photon irradiation using a water bath technique for treatment of confluent carcinoma in situ of the hand, digits, and nail bed: a case report". J Med Case Rep. 11 (1): 86. doi:10.1186/s13256-017-1233-3. PMC 5372342. PMID 28356127.
  39. Hunt WT, Cameron A, Craig P, de Berker DA (2013). "Multiple-digit periungual Bowen's disease: a novel treatment approach with radiotherapy". Clin Exp Dermatol. 38 (8): 857–61. doi:10.1111/ced.12149. PMID 23937119.
  40. Dupree MT, Kiteley RA, Weismantle K, Panos R, Johnstone PA (2001). "Radiation therapy for Bowen's disease: lessons for lesions of the lower extremity". J Am Acad Dermatol. 45 (3): 401–4. doi:10.1067/mjd.2001.116581. PMID 11511838.
  41. "Extramammary Paget Disease - StatPearls - NCBI Bookshelf".
  42. Yao H, Xie M, Fu S, Guo J, Peng Y, Cai Z; et al. (2018). "Survival analysis of patients with invasive extramammary Paget disease: implications of anatomic sites". BMC Cancer. 18 (1): 403. doi:10.1186/s12885-018-4257-1. PMC 5894213. PMID 29636019.
  43. Karam A, Dorigo O (2014). "Increased risk and pattern of secondary malignancies in patients with invasive extramammary Paget disease". Br J Dermatol. 170 (3): 661–71. doi:10.1111/bjd.12635. PMID 24617434.
  44. van der Zwan JM, Siesling S, Blokx WA, Pierie JP, Capocaccia R (2012). "Invasive extramammary Paget's disease and the risk for secondary tumours in Europe". Eur J Surg Oncol. 38 (3): 214–21. doi:10.1016/j.ejso.2011.12.008. PMID 22244907.
  45. Asel M, LeBoeuf NR (2019). "Extramammary Paget's Disease". Hematol Oncol Clin North Am. 33 (1): 73–85. doi:10.1016/j.hoc.2018.09.003. PMID 30497678.
  46. Chumbalkar V, Jennings TA, Ainechi S, Lee EC, Lee H (2016). "Extramammary Paget's Disease of Anal Canal Associated With Rectal Adenoma Without Invasive Carcinoma". Gastroenterology Res. 9 (6): 99–102. doi:10.14740/gr727e. PMC 5191897. PMID 28058078.
  47. Jabir S, Khatib M, Ali S, Niranjan N (2013). "Perianal Paget's disease: a diagnostic dilemma". BMJ Case Rep. 2013. doi:10.1136/bcr-2013-200504. PMC 3794179. PMID 24072832.
  48. Tarng SJ, Fan HA, Lin SE, Lai CR, Tang RP, You YD; et al. (1990). "Perianal Paget's disease--report of 4 cases". Changgeng Yi Xue Za Zhi. 13 (4): 314–21. PMID 2178040.
  49. Lian P, Gu WL, Zhang Z, Cai GX, Wang MH, Xu Y; et al. (2010). "Retrospective analysis of perianal Paget's disease with underlying anorectal carcinoma". World J Gastroenterol. 16 (23): 2943–8. doi:10.3748/wjg.v16.i23.2943. PMC 2887592. PMID 20556842.
  50. {{cite journal| author=Rajendran S, Koh CE, Solomon MJ| title=Extramammary Paget's disease of the perianal region: a 20-year experience. | journal=ANZ J Surg | year= 2017 | volume= 87 | issue= 3 | pages= 132-137 | pmid=25113623 | doi=10.1111/ans.12814 | pmc= | <ref name="pmid27746643">Nagai Y, Kazama S, Yamada D, Miyagawa T, Murono K, Yasuda K; et al. (2016). "Perianal and Vulvar Extramammary Paget Disease: A Report of Six Cases and Mapping Biopsy of the Anal Canal". Ann Dermatol. 28 (5): 624–628. doi:10.5021/ad.2016.28.5.624. PMC 5064193. PMID 27746643.
  51. Jung JH, Kwak C, Kim HH, Ku JH (2013). "Extramammary Paget Disease of External Genitalia: Surgical Excision and Follow-up Experiences With 19 Patients". Korean J Urol. 54 (12): 834–9. doi:10.4111/kju.2013.54.12.834. PMC 3866286. PMID 24363864.
  52. Yang WJ, Kim DS, Im YJ, Cho KS, Rha KH, Cho NH; et al. (2005). "Extramammary Paget's disease of penis and scrotum". Urology. 65 (5): 972–5. doi:10.1016/j.urology.2004.12.010. PMID 15882734.
  53. Fu M, Gao S, Wang P (1999). "[19 cases of Paget's disease]". Zhonghua Wai Ke Za Zhi. 37 (7): 429–31. PMID 11829881.
  54. "Extramammary Paget's disease of the perianal region: a 20‐year experience - Rajendran - 2017 - ANZ Journal of Surgery - Wiley Online Library".



Linked-in.jpg