Bile acid-CoA:amino acid N-acyltransferase

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In enzymology, a bile acid-CoA:amino acid N-acyltransferase (EC 2.3.1.65) is an enzyme that catalyzes the chemical reaction

choloyl-CoA + glycine CoA + glycocholate

Thus, the two substrates of this enzyme are choloyl-CoA and glycine, whereas its two products are CoA and glycocholate.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is choloyl-CoA:glycine N-choloyltransferase. Other names in common use include glycine-taurine N-acyltransferase, amino acid N-choloyltransferase, BAT, glycine N-choloyltransferase, BACAT, cholyl-CoA glycine-taurine N-acyltransferase, and cholyl-CoA:taurine N-acyltransferase. This enzyme participates in bile acid biosynthesis and taurine and hypotaurine metabolism.

References

  • IUBMB entry for 2.3.1.65
  • BRENDA references for 2.3.1.65 (Recommended.)
  • PubMed references for 2.3.1.65
  • PubMed Central references for 2.3.1.65
  • Google Scholar references for 2.3.1.65
  • Czuba B, Vessey DA (1980). "Kinetic characterization of cholyl-CoA glycine-taurine N-acyltransferase from bovine liver". J. Biol. Chem. 255: 5296&ndash, 9. PMID 7372637.
  • Jordan TW, Lee R and Lim WC (1980). "Isoelectric focussing of soluble and particulate benzoyl-CoA and cholyl-CoA:amino acid N-acyltransferases from rat liver". Biochem. Int. 1: 325&ndash, 330.
  • Vessey DA (1979). "The co-purification and common identity of cholyl CoA:glycine- and cholyl CoA:taurine-N-acyltransferase activities from bovine liver". J. Biol. Chem. 254: 2059&ndash, 63. PMID 422567.
  • Johnson MR, Barnes S, Kwakye JB, Diasio RB (1991). "Purification and characterization of bile acid-CoA:amino acid N-acyltransferase from human liver". J. Biol. Chem. 266: 10227&ndash, 33. PMID 2037576.
  • Falany CN, Xie X, Wheeler JB, Wang J, Smith M, He D, Barnes S (2002). "Molecular cloning and expression of rat liver bile acid CoA ligase". J. Lipid. Res. 43: 2062&ndash, 71. PMID 12454267.
  • He D, Barnes S, Falany CN (2003). "Rat liver bile acid CoA:amino acid N-acyltransferase: expression, characterization, and peroxisomal localization". J. Lipid. Res. 44: 2242&ndash, 9. PMID 12951368.
  • O'Byrne J, Hunt MC, Rai DK, Saeki M, Alexson SE (2003). "The human bile acid-CoA:amino acid N-acyltransferase functions in the conjugation of fatty acids to glycine". J. Biol. Chem. 278: 34237&ndash, 44. PMID 12810727.

External links

The CAS registry number for this enzyme class is 74506-32-4.

Gene Ontology (GO) codes


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