BPI fold containing family B, member 1 is a protein that in humans is encoded by the BPIFB1 gene.
The protein encoded by this gene may be involved in the innate immune response to bacterial exposure in the mouth, nasal cavities, and lungs. The encoded protein is secreted and is a member of the BPI/LBP/PLUNC protein superfamily. This gene is found with other members of the superfamily in a cluster on chromosome 20. [provided by RefSeq, Jul 2008].
Model organisms have been used in the study of BPIFB1 function. A conditional knockout mouse line called Bpifb1 was generated at the tm1e(KOMP)Wtsi Wellcome Trust Sanger Institute. Male and female animals underwent a standardized  phenotypic screen to determine the effects of deletion.     Additional screens performed: - In-depth immunological phenotyping  - in-depth bone and cartilage phenotyping 
Bpifb1 knockout mouse phenotype
All data available at.  
Peripheral blood leukocytes 6 Weeks
6 Weeks Haematology Normal
Homozygous viability at P14
Indirect calorimetry Normal
Glucose tolerance test Normal
Auditory brainstem response Normal
Clinical chemistry Normal
16 Weeks Haematology Normal
Peripheral blood leukocytes 16 Weeks
infection Salmonella Normal
Cytotoxic T Cell Function
Mesenteric Lymph Node Immunophenotyping
Bone Marrow Immunophenotyping
Epidermal Immune Composition
"Entrez Gene: BPI fold containing family B, member 1".
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