BIRC6

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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Baculoviral IAP repeat-containing protein 6 is a protein that in humans is encoded by the BIRC6 gene.[1][2]

Function

This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination.[2]

Interactions

BIRC6 has been shown to interact with KIF23.[3]

Diseases

BIRC6 is implicated in leukemia, melanoma, breast cancer, lung cancer, colorectal cancer, and other cancers[4] (see the Atlas of Genetics and Cytogenetics in Oncology and Haematology[5]).

References

  1. Chen Z, Naito M, Hori S, Mashima T, Yamori T, Tsuruo T (Dec 1999). "A human IAP-family gene, apollon, expressed in human brain cancer cells". Biochem Biophys Res Commun. 264 (3): 847–54. doi:10.1006/bbrc.1999.1585. PMID 10544019.
  2. 2.0 2.1 "Entrez Gene: BIRC6 baculoviral IAP repeat-containing 6 (apollon)".
  3. Pohl C, Jentsch S (Mar 2008). "Final stages of cytokinesis and midbody ring formation are controlled by BRUCE". Cell. 132 (5): 832–45. doi:10.1016/j.cell.2008.01.012. PMID 18329369.
  4. "BIRC6 (Baculoviral IAP repeat-containing 6)". atlasgeneticsoncology.org.
  5. "Atlas of Genetics and Cytogenetics in Oncology and Haematology". atlasgeneticsoncology.org.

External links

Further reading



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