Aspartate-ammonia ligase (ADP-forming)

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In enzymology, an aspartate-ammonia ligase (ADP-forming) (EC is an enzyme that catalyzes the chemical reaction

ATP + L-aspartate + NH3 ADP + phosphate + L-asparagine

The 3 substrates of this enzyme are ATP, L-aspartate, and NH3, whereas its 3 products are ADP, phosphate, and L-asparagine.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-ammonia (or amine) ligases (amide synthases). The systematic name of this enzyme class is L-aspartate:ammonia ligase (ADP-forming). Other names in common use include asparagine synthetase (ADP-forming), and asparagine synthetase (adenosine diphosphate-forming). This enzyme participates in nitrogen metabolism.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Nair PM (1969). "Asparagine synthetase from gamma-irradiated potatoes". Arch. Biochem. Biophys. 133: 208&ndash, 15. PMID 5820987.

External links

The CAS registry number for this enzyme class is 37318-61-9.

Gene Ontology (GO) codes