Asparagine-tRNA ligase

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In enzymology, an asparagine-tRNA ligase (EC is an enzyme that catalyzes the chemical reaction

ATP + L-asparagine + tRNAAsn AMP + diphosphate + L-asparaginyl-tRNAAsn

The 3 substrates of this enzyme are ATP, L-asparagine, and tRNA(Asn), whereas its 3 products are AMP, diphosphate, and L-asparaginyl-tRNA(Asn).

This enzyme belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-asparagine:tRNAAsn ligase (AMP-forming). Other names in common use include asparaginyl-tRNA synthetase, asparaginyl-transfer ribonucleate synthetase, asparaginyl transfer RNA synthetase, asparaginyl transfer ribonucleic acid synthetase, asparagyl-transfer RNA synthetase, and asparagine translase. This enzyme participates in alanine and aspartate metabolism and aminoacyl-trna biosynthesis.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1X54, 1X55, and 1X56.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Davies MR, Marshall RD (1972). "Partial purification of L-asparaginyl-tRNA synthetase from rabbit liver". Biochem. Biophys. Res. Commun. 47: 1386&ndash, 95. PMID 5040239.

External links

The CAS registry number for this enzyme class is 37211-76-0.

Gene Ontology (GO) codes