Asialoglycoprotein receptor

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asialoglycoprotein receptor 1
Identifiers
SymbolASGR1
Entrez432
HUGO742
OMIM108360
RefSeqNM_001671
UniProtP07306
Other data
LocusChr. 17 p13-p11
asialoglycoprotein receptor 2
Identifiers
SymbolASGR2
Entrez433
HUGO743
OMIM108361
RefSeqNM_080914
UniProtP07307
Other data
LocusChr. 17 p

The asialoglycoprotein receptors are lectins which bind asialoglycoprotein and glycoproteins from which a sialic acid has been removed to expose galactose residues. The receptors, which are located on liver cells, remove the target glycoproteins from circulation. The asialoglycoprotein receptor has been demonstrated to have high expression on the surface of hepatocytes and several human carcinoma cell lines. Lactobionic acid has been used as a targeting moiety for drug delivery to cells expressing asialoglycoprotein receptors.[1]

References

  1. Roggenbuck D, Mytilinaiou MG, Lapin SV, Reinhold D, Conrad K (December 2012). "Asialoglycoprotein receptor (ASGPR): a peculiar target of liver-specific autoimmunity". Auto- Immunity Highlights. 3 (3): 119–25. doi:10.1007/s13317-012-0041-4. PMC 4389076. PMID 26000135.

External links


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