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If terminal sialic acid residues are removed from glycoproteins, the resulting proteins are known as asialoglycoproteins.

These are transmembrane proteins where the amino terminal is cytosolic and the carboxyl terminal is exoplasmic.

These proteins have a single internal hydrophobic signal-anchor sequence that serves both as the endoplasmic reticulum signal peptide and a membrane-anchor sequence. The signal-anchor sequence is recognised by a Signal recognition particle (SRP) and is forced into the appropriate translocon to continue translation of the protein.

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