Arginine vasopressin receptor 1A

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Arginine vasopressin receptor 1A
Identifiers
Symbols AVPR1A ; AVPR1
External IDs OMIM: 600821 MGI1859216 HomoloGene568
RNA expression pattern
PBB GE AVPR1A 206251 s at tn.png
PBB GE AVPR1A 206250 x at tn.png
PBB GE AVPR1A 206252 s at tn.png
More reference expression data
Orthologs

| | bgcolor="#C3FDB8" | Human | bgcolor="#C3FDB8" | Mouse |-

    | bgcolor="#C3FDB8" | Entrez 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 552
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 54140

|-

     | bgcolor="#C3FDB8" | Ensembl
     | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| ENSG00000166148
     | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| ENSMUSG00000020123

|-

    | bgcolor="#C3FDB8" | Uniprot
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| P37288
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| Q3U1H9

|-

    | bgcolor="#C3FDB8" | Refseq
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" | NM_000706 (mRNA)
NP_000697 (protein)
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" |NM_016847 (mRNA)
NP_058543 (protein)

|-

    | bgcolor="#C3FDB8" | Location
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"|  Chr 12: 61.83 - 61.83 Mb 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"|  Chr 10: 121.85 -  121.86 Mb 

|-

|-

    | bgcolor="#C3FDB8" | Pubmed search 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [1]
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [2]
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Arginine vasopressin receptor 1A (AVPR1A) is a protein that acts as receptor for arginine vasopressin.[1] AVPR1A belongs to the subfamily of G-protein coupled receptors.

Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system.

The activity / genetic variants of the AVPR1 gene might be related to generosity and altruistic behavior.[2]

References

  1. Thibonnier M, Auzan C, Madhun Z, Wilkins P, Berti-Mattera L, Clauser E (1994). "Molecular cloning, sequencing, and functional expression of a cDNA encoding the human V1a vasopressin receptor". J. Biol. Chem. 269 (5): 3304–10. PMID 8106369.
  2. Knafo A, Israel S, Darvasi A, Bachner-Melman R, Uzefovsky F, Cohen L, Feldman E, Lerer E, Laiba E, Raz Y, Nemanov L, Gritsenko I, Dina C, Agam G, Dean B, Bornstein G, Ebstein RP (2007). "Individual differences in allocation of funds in the dictator game associated with length of the arginine vasopressin 1a receptor RS3 promoter region and correlation between RS3 length and hippocampal mRNA". Genes Brain Behav. doi:10.1111/j.1601-183X.2007.00341.x. PMID 17696996.

Further reading

  • Thibonnier M, Coles P, Thibonnier A, Shoham M (2002). "Molecular pharmacology and modeling of vasopressin receptors". Prog. Brain Res. 139: 179–96. PMID 12436935.
  • Cross SH, Charlton JA, Nan X, Bird AP (1994). "Purification of CpG islands using a methylated DNA binding column". Nat. Genet. 6 (3): 236–44. doi:10.1038/ng0394-236. PMID 8012384.
  • Hirasawa A, Shibata K, Kotosai K, Tsujimoto G (1994). "Cloning, functional expression and tissue distribution of human cDNA for the vascular-type vasopressin receptor". Biochem. Biophys. Res. Commun. 203 (1): 72–9. doi:10.1006/bbrc.1994.2150. PMID 8074728.
  • Thibonnier M, Auzan C, Madhun Z; et al. (1994). "Molecular cloning, sequencing, and functional expression of a cDNA encoding the human V1a vasopressin receptor". J. Biol. Chem. 269 (5): 3304–10. PMID 8106369.
  • Young WS, Kovács K, Lolait SJ (1993). "The diurnal rhythm in vasopressin V1a receptor expression in the suprachiasmatic nucleus is not dependent on vasopressin". Endocrinology. 133 (2): 585–90. PMID 8344200.
  • Thibonnier M, Graves MK, Wagner MS; et al. (1997). "Structure, sequence, expression, and chromosomal localization of the human V1a vasopressin receptor gene". Genomics. 31 (3): 327–34. doi:10.1006/geno.1996.0055. PMID 8838314.
  • North WG, Fay MJ, Longo K, Du J (1998). "Functional vasopressin V1 type receptors are present in variant as well as classical forms of small-cell carcinoma". Peptides. 18 (7): 985–93. PMID 9357056.
  • North WG, Fay MJ, Longo KA, Du J (1998). "Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide". Cancer Res. 58 (9): 1866–71. PMID 9581826.
  • North WG, Fay MJ, Du J (1999). "MCF-7 breast cancer cells express normal forms of all vasopressin receptors plus an abnormal V2R". Peptides. 20 (7): 837–42. PMID 10477084.
  • Tahara A, Tsukada J, Ishii N; et al. (1999). "Comparison of vasopressin binding sites in human uterine and vascular smooth muscle cells". Eur. J. Pharmacol. 378 (1): 137–42. PMID 10478574.
  • Thibonnier M, Graves MK, Wagner MS; et al. (2000). "Study of V(1)-vascular vasopressin receptor gene microsatellite polymorphisms in human essential hypertension". J. Mol. Cell. Cardiol. 32 (4): 557–64. doi:10.1006/jmcc.2000.1108. PMID 10756113.
  • Berrada K, Plesnicher CL, Luo X, Thibonnier M (2000). "Dynamic interaction of human vasopressin/oxytocin receptor subtypes with G protein-coupled receptor kinases and protein kinase C after agonist stimulation". J. Biol. Chem. 275 (35): 27229–37. doi:10.1074/jbc.M002288200. PMID 10858434.
  • Kim SJ, Young LJ, Gonen D; et al. (2002). "Transmission disequilibrium testing of arginine vasopressin receptor 1A (AVPR1A) polymorphisms in autism". Mol. Psychiatry. 7 (5): 503–7. doi:10.1038/sj.mp.4001125. PMID 12082568.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Tahtaoui C, Balestre MN, Klotz P; et al. (2003). "Identification of the binding sites of the SR49059 nonpeptide antagonist into the V1a vasopressin receptor using sulfydryl-reactive ligands and cysteine mutants as chemical sensors". J. Biol. Chem. 278 (41): 40010–9. doi:10.1074/jbc.M301128200. PMID 12869559.
  • Hawtin SR, Wesley VJ, Simms J; et al. (2004). "An arginyl in the N-terminus of the V1a vasopressin receptor is part of the conformational switch controlling activation by agonist". Eur. J. Biochem. 270 (23): 4681–8. PMID 14622255.
  • Terrillon S, Barberis C, Bouvier M (2004). "Heterodimerization of V1a and V2 vasopressin receptors determines the interaction with beta-arrestin and their trafficking patterns". Proc. Natl. Acad. Sci. U.S.A. 101 (6): 1548–53. doi:10.1073/pnas.0305322101. PMID 14757828.
  • Wassink TH, Piven J, Vieland VJ; et al. (2005). "Examination of AVPR1a as an autism susceptibility gene". Mol. Psychiatry. 9 (10): 968–72. doi:10.1038/sj.mp.4001503. PMID 15098001.
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.

External links


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