Aquaporin 3

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aquaporin 3 (Gill blood group)
Symbol AQP3
Entrez 360
HUGO 636
OMIM 600170
RefSeq NM_004925
UniProt Q92482
Other data
Locus Chr. 9 p13

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Aquaporin 3 is found in the basolateral cell membrane of principal collecting duct cells and provide a pathway for water to exit these cells.[1] In kidney, AQP3 gene expression is not regulated by vasopressin (ADH).[2] This protein is also a determinant for the GIL blood group system.[3]

See also


  1. Sasaki S, Ishibashi K, Marumo F (1998). "Aquaporin-2 and -3: representatives of two subgroups of the aquaporin family colocalized in the kidney collecting duct". Annu. Rev. Physiol. 60: 199–220. PMID 9558461. doi:10.1146/annurev.physiol.60.1.199. 
  2. Dibas AI, Mia AJ, Yorio T (1998). "Aquaporins (water channels): role in vasopressin-activated water transport". Proc. Soc. Exp. Biol. Med. 219 (3): 183–99. PMID 9824541. 
  3. Roudier N, Ripoche P, Gane P, Le Pennec PY, Daniels G, Cartron JP, Bailly P (2002). "AQP3 deficiency in humans and the molecular basis of a novel blood group system, GIL". J. Biol. Chem. 277 (48): 45854–9. PMID 12239222. doi:10.1074/jbc.M208999200. 

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