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An anxiogenic substance is one that causes anxiety. Anxiogenic effects can be measured by, for example, the hole-board test in rats and mice.[1]. A number of agents are used to provoke anxiety (anxiogenes) or panic (panicogenes) in experimental models . Some of the most common substances are: DMCM, sodium lactate, carbon dioxide (CO2), caffeine, yohimbine, serotoninergic agents, adrenergic agents and cholecystokinin (CCK)[1]

Anxiolytic substances have the opposite effect: they reduce anxiety.


  1. Takeda, H and Tsuji, M and Matsumiya, T (1998). "Changes in head-dipping behavior in the hole-board test reflect the anxiogenic and/or anxiolytic state in mice". European Journal of Pharmacology. 350 (1): 21&ndash, 29.