Antifibrinolytic

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Antifibrinolytics, such as aminocaproic acid (ε-aminocaproic acid) and tranexamic acid are used as inhibitors of fibrinolysis, which act by blocking the lysine-binding site on plasmin.

Tranexamic acid may reduce bleeding after orthopedic surgery[1]. Tranexamic acid may better than aminocaproic acid for reducing estimated blood loss in orthopedic surgery[2].

Tranexamic acid may reduce bleeding after trauma[3].


They are used in menorrhagia and bleeding tendency due to various causes.

References

  1. Sun Y, Jiang C, Li Q (2017). "A systematic review and meta-analysis comparing combined intravenous and topical tranexamic acid with intravenous administration alone in THA.". PLoS One. 12 (10): e0186174. PMC 5634626Freely accessible. PMID 29016673. doi:10.1371/journal.pone.0186174. 
  2. Boese CK, Centeno L, Walters RW (2017). "Blood Conservation Using Tranexamic Acid Is Not Superior to Epsilon-Aminocaproic Acid After Total Knee Arthroplasty.". J Bone Joint Surg Am. 99 (19): 1621–1628. PMID 28976426. doi:10.2106/JBJS.16.00738. 
  3. Ker K, Roberts I, Shakur H, Coats TJ (2015). "Antifibrinolytic drugs for acute traumatic injury.". Cochrane Database Syst Rev (5): CD004896. PMID 25956410. doi:10.1002/14651858.CD004896.pub4. 

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