Alpha 2-antiplasmin

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Identifiers
Symbol SERPINF2
Alt. Symbols PLI
Entrez 5345
HUGO 9075
OMIM 262850
RefSeq NM_000934
UniProt P08697
Other data
Locus Chr. 17 pter-p12

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List of terms related to Alpha 2-antiplasmin

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Alpha 2-antiplasmin (or α2-antiplasmin or plasmin inhibitor) is a serine protease inhibitor (serpin) responsible for inactivating plasmin, an important enzyme that participates in fibrinolysis and degradation of various other proteins.

Fibrinolysis (simplified). Blue arrows denote stimulation, and red arrows inhibition.

Role in disease

Very few cases (<20) of A2AP deficiency have been described. As plasmin degrades blood clots, impaired inhibition of plasmin leads to a bleeding tendency, which was severe in the cases reported.

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