Alpha 1-antichymotrypsin

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serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
Identifiers
Symbol SERPINA3
Alt. Symbols AACT
Entrez 12
HUGO 16
OMIM 107280
RefSeq NM_001085
UniProt P01011
Other data
Locus Chr. 14 q32.1

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Alpha 1-antichymotrypsin is an alpha globulin glycoprotein that is a member of the serine proteinase inhibitor (serpin) family.

It inhibits the activity of certain enzymes called proteinases, such as cathepsin G that is found in neutrophils, and chymases found in mast cells, by cleaving them into a different shape or conformation. This activity protects some tissues, such as the lower respiratory tract, from damage caused by proteolytic enzymes.[1]

Alpha 1-antichymotrypsin is also associated with the pathogenesis of Alzheimer's disease as it enhances the formation of amyloid-fibrils in this disease.[1]

This enzyme is produced in the liver, and is an acute phase protein that is induced during inflammation.

References

  1. 1.0 1.1 Kalsheker N (1996). "Alpha 1-antichymotrypsin". Int. J. Biochem. Cell Biol. 28 (9): 961–4. PMID 8930118. 

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