Allodynia

Jump to: navigation, search
Allodynia

WikiDoc Resources for Allodynia

Articles

Most recent articles on Allodynia

Most cited articles on Allodynia

Review articles on Allodynia

Articles on Allodynia in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Allodynia

Images of Allodynia

Photos of Allodynia

Podcasts & MP3s on Allodynia

Videos on Allodynia

Evidence Based Medicine

Cochrane Collaboration on Allodynia

Bandolier on Allodynia

TRIP on Allodynia

Clinical Trials

Ongoing Trials on Allodynia at Clinical Trials.gov

Trial results on Allodynia

Clinical Trials on Allodynia at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Allodynia

NICE Guidance on Allodynia

NHS PRODIGY Guidance

FDA on Allodynia

CDC on Allodynia

Books

Books on Allodynia

News

Allodynia in the news

Be alerted to news on Allodynia

News trends on Allodynia

Commentary

Blogs on Allodynia

Definitions

Definitions of Allodynia

Patient Resources / Community

Patient resources on Allodynia

Discussion groups on Allodynia

Patient Handouts on Allodynia

Directions to Hospitals Treating Allodynia

Risk calculators and risk factors for Allodynia

Healthcare Provider Resources

Symptoms of Allodynia

Causes & Risk Factors for Allodynia

Diagnostic studies for Allodynia

Treatment of Allodynia

Continuing Medical Education (CME)

CME Programs on Allodynia

International

Allodynia en Espanol

Allodynia en Francais

Business

Allodynia in the Marketplace

Patents on Allodynia

Experimental / Informatics

List of terms related to Allodynia


Allodynia, meaning "other pain", is an exaggerated response to otherwise non-noxious stimuli and can be either static or mechanical. Allodynia is not referred pain, but can occur in other areas than the one stimulated; it is also dysesthetic.

For example, a person with allodynia may perceive light pressure or the movement of clothes over the skin as painful, whereas a healthy individual will not feel pain.

Pathophysiology

One explanation of the mechanism for allodynia is that the associated nerve damage results in decreased firing thresholds of nociceptive fibres.

Alternatively, it has been postulated that peripheral nerve injury could induce collateral sprouting of non-nociceptive primary afferent neurones, such as A-beta low threshold mechanoreceptors, into the superficial (nociceptive) laminae in the dorsal horn of the spinal cord. These collateral branches could form functional contacts with nociceptive second order neurons, normally innervated by C-fibre nociceptive primary afferent neurones and transmit an innocous input as noxious.

Associated disturbances

Allodynia is a clinical feature of pain conditions such as migraine, postherpetic neuralgia, fibromyalgia, and neuropathies.

Types

There are different kinds or types of allodynia:

  • Mechanical allodynia (also known as tactile allodynia) - Pain from light touch/pressure applied to the skin in the area of the damaged nerve. Mechanical allodynia can be dynamic or static. Also it has been shown that lowering barometric pressure aggravates mechanical allodynia in a rat model of neuropathic pain
  • Thermal (heat or cold) allodynia - Pain from normally mild skin temperatures in the affected area.




Linked-in.jpg