Aggregatibacter actinomycetemcomitans

Jump to: navigation, search

WikiDoc Resources for Aggregatibacter actinomycetemcomitans

Articles

Most recent articles on Aggregatibacter actinomycetemcomitans

Most cited articles on Aggregatibacter actinomycetemcomitans

Review articles on Aggregatibacter actinomycetemcomitans

Articles on Aggregatibacter actinomycetemcomitans in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Aggregatibacter actinomycetemcomitans

Images of Aggregatibacter actinomycetemcomitans

Photos of Aggregatibacter actinomycetemcomitans

Podcasts & MP3s on Aggregatibacter actinomycetemcomitans

Videos on Aggregatibacter actinomycetemcomitans

Evidence Based Medicine

Cochrane Collaboration on Aggregatibacter actinomycetemcomitans

Bandolier on Aggregatibacter actinomycetemcomitans

TRIP on Aggregatibacter actinomycetemcomitans

Clinical Trials

Ongoing Trials on Aggregatibacter actinomycetemcomitans at Clinical Trials.gov

Trial results on Aggregatibacter actinomycetemcomitans

Clinical Trials on Aggregatibacter actinomycetemcomitans at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Aggregatibacter actinomycetemcomitans

NICE Guidance on Aggregatibacter actinomycetemcomitans

NHS PRODIGY Guidance

FDA on Aggregatibacter actinomycetemcomitans

CDC on Aggregatibacter actinomycetemcomitans

Books

Books on Aggregatibacter actinomycetemcomitans

News

Aggregatibacter actinomycetemcomitans in the news

Be alerted to news on Aggregatibacter actinomycetemcomitans

News trends on Aggregatibacter actinomycetemcomitans

Commentary

Blogs on Aggregatibacter actinomycetemcomitans

Definitions

Definitions of Aggregatibacter actinomycetemcomitans

Patient Resources / Community

Patient resources on Aggregatibacter actinomycetemcomitans

Discussion groups on Aggregatibacter actinomycetemcomitans

Patient Handouts on Aggregatibacter actinomycetemcomitans

Directions to Hospitals Treating Aggregatibacter actinomycetemcomitans

Risk calculators and risk factors for Aggregatibacter actinomycetemcomitans

Healthcare Provider Resources

Symptoms of Aggregatibacter actinomycetemcomitans

Causes & Risk Factors for Aggregatibacter actinomycetemcomitans

Diagnostic studies for Aggregatibacter actinomycetemcomitans

Treatment of Aggregatibacter actinomycetemcomitans

Continuing Medical Education (CME)

CME Programs on Aggregatibacter actinomycetemcomitans

International

Aggregatibacter actinomycetemcomitans en Espanol

Aggregatibacter actinomycetemcomitans en Francais

Business

Aggregatibacter actinomycetemcomitans in the Marketplace

Patents on Aggregatibacter actinomycetemcomitans

Experimental / Informatics

List of terms related to Aggregatibacter actinomycetemcomitans


Overview

Aggregatibacter actinomycetemcomitans is an oral commensal found also in severe infections in the oral cavity, mainly the periodontium. A. actinomycetemcomitans, previously Actinobacillus actinomycetemcomitans, is a gram negative facultative non motile rod. It is also associated with non oral infections.

Nomenclature

Recent studies have shown a phylogenetic similarity of Actinobacillus actinomycetemcomitans and Haemophilus aphrophilus, Haemophilus paraphrophilus, and Haemophilus segnis suggesting the new genus Aggregatibacter for them[1]. Now or before, the bacterium still holds the longest binomial nomenclature name of a living thing.

Importance

It is one of the bacteria which might be implicated in destructive periodontal disease. Although it has been found more frequently in localized aggressive periodontitis,[2], prevalence in any population is rather high. It has also been isolated from actinomycotic lesions (mixed infection with certain Actinomyces species, in particular Actinomyces israelii). It possesses certain virulence factors that enable it to invade tissues, such as leukotoxin.

Virulence Factors

- Leukotoxin; kills PMN's and monocytes.

- Immunosuppression factors that inhibit blastogenesis, antibody production and activate T-suppressor cells

- Inhibition of PMN's functions

- Resistant to complement mediated killing.

A. actinomycetemcomitans Serotypes

- a strain, for example ATCC 29523, frequently in oral cavity, variable leukotoxin expression.

- b strain Y4, most frequently in localized aggressive periodontitis, leukotoxin expression.

- c strain ATCC 33384, low leukotoxin.

- serotypes d, e

References

  1. Norskov-Lauritsen N., Kilian M. Int J Syst Evol Microbiol. 2006 Sep;56(Pt 9):2135-46.
  2. Slots J. Scand J Dent Res; 1976 Jan;84(1):1-10.




Linked-in.jpg