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In enzymology, an adenylylsulfatase (EC is an enzyme that catalyzes the chemical reaction

adenylyl sulfate + H2O AMP + sulfate

Thus, the two substrates of this enzyme are adenylyl sulfate and H2O, whereas its two products are AMP and sulfate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in sulfonyl-containing anhydrides. The systematic name of this enzyme class is adenylyl-sulfate sulfohydrolase. Other names in common use include adenosine 5-phosphosulfate sulfohydrolase, and adenylylsulfate sulfohydrolase. This enzyme participates in sulfur metabolism.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
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  • Bailey-Wood R, Dodgson KS, Rose FA (1969). "A rat liver sulphohydrolase enzyme acting on adenylyl sulphate". Biochem. J. 112: 257&ndash, 8. PMID 5801298.

External links

The CAS registry number for this enzyme class is 37289-36-4.

Gene Ontology (GO) codes