Acute myeloblastic leukemia with maturation

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Acute myeloblastic leukemia with maturation
Myeloblast.png
Myeloblast
ICD-O: M9874/3
MeSH D015470

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


M2 is a subtype of AML (Acute Myeloid Leukemia).

It is also known as "Acute Myeloblastic Leukemia with Maturation".[1]

Cause

This subtype is characterized by a translocation of a part of chromosome 8 to chromosome 21, written as t(8;21).[2] On both sides of the chromosome, now containing pieces from two chromosomes, the DNA codes for different proteins. These two proteins are now being created as one single large protein, with a different effect in the body as the two proteins originally coded by the two different chromosomes.

The two different proteins that are fused together are:

References

  1. "Acute Myeloid Leukemia - Signs and Symptoms". 
  2. Taj AS, Ross FM, Vickers M; et al. (1995). "t(8;21) myelodysplasia, an early presentation of M2 AML". Br. J. Haematol. 89 (4): 890–2. PMID 7772527. 

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